老年医学与保健2023，Vol.29Issue(6)：1314-1318,1331,6.
基于网络药理学探讨黄芪改善原发性肌肉减少症的作用机制
The mechanism of Astragali Radix improving primary sarcopenia based on network pharmacology
崔梦 1王璐华 1严懿嘉 1陈志龙1
作者信息
- 1. 复旦大学附属华东医院药剂科,上海 200040
- 折叠
摘要
Abstract
Objective Primary sarcopenia is an age-related skeletal muscle disease.This article aimed to explore the ef-fective active ingredients and therapeutic targets of Astragali Radix for primary sarcopenia.Methods In this study,network pharmacology was used to explore the mechanism of Astragali Radix in the treatment of sarcopenia.Firstly,in the Traditional Chinese Medicine System Pharmacology Database(TCMSP)and Protein Database(Uniprot),the effective active ingredients and corresponding gene targets of Astragali Radix were screened.Next,gene targets related to primary sarcopenia were collect-ed through four databases:GeneCard,OMIM,PharmGkb,and TTD.Then,the intersection of the drug gene targets and dis-ease-related genes was taken to construct the Astragali Radix-active ingredient-sarcopenia-target gene regulatory network.A protein-protein interaction(PPI)network of intersecting target genes associated with Astragalus Radix-primary sarcopenia was visualized using the String platform.Gene ontology(GO)enrichment analysis revealed the characteristic biological properties of these targets.Additionally,Kyoto Encyclopedia of Genes and Genomes(KEGG)pathway analysis was conducted..Results 20 effective active ingredients of Astragali Radix were obtained from the databases,with 181 Astragali Radix action targets and 498 gene targets related to primary sarcopenia.After taking the intersection,16 key targets were acquired.Astragali Radix may exert therapeutic effects by mediating cellular responses to oxidative stress,chemical stress and other signaling pathways through antioxidant,anti-inflammatory,and immune regulation.Conclusion Astragali Radix may improve the symptoms of elderly sarcopenia by acting on multiple gene targets through its multiple active ingredients.This provides theoretical support for the ap-plication of Astragali Radix in the clinical treatment of elderly sarcopenia.关键词
老年/黄芪/原发性肌肉减少症/网络药理学Key words
elderly/Astragali Radix/primary sarcopenia/network pharmacology引用本文复制引用
崔梦,王璐华,严懿嘉,陈志龙..基于网络药理学探讨黄芪改善原发性肌肉减少症的作用机制[J].老年医学与保健,2023,29(6):1314-1318,1331,6.
