临床误诊误治2023，Vol.36Issue(9)：38-42,5.DOI:10.3969/j.issn.1002-3429.2023.09.009
不同SRBS:FFP配比输注对急性创伤大出血患者凝血功能的影响
Effect of Infusion with Different RBCS:FFP Ratio on Coagulation Func-tion in Patients with Acute Massive Traumatic Hemorrhage
摘要
Abstract
Objective To investigate the effects of infusion with different suspended red blood cells(SRBC):fresh frozen plasma(FFP)ratio on coagulation function in patients with acute massive traumatic hemorrhage.Methods In total,100 patients with acute traumatic hemorrhage admitted from June 2019 to February 2023 were divided into different groups ac-cording to the SRBS ︰ FFP ratio of transfusion therapy,including group A(SRBS ︰ FFP≥2 ︰1,n = 32),group B(SRBS︰FFP＜2︰1-1︰1,n =35),and group C(RBCS︰FFP＜1︰1,n =33).The blood product infusion vol-ume,and changes in blood routine and coagulation indexes before and after transfusion were compared among the three groups.Results The FFP infusion volume in group C was higher than that in group B,and higher in group B than in group A(P＜0.05).After blood transfusion,hemoglobin(Hb)of the three groups was higher than that before blood transfusion(P＜0.05),while platelet(PLT)of the three groups was significantly decreased after blood transfusion(P＜0.05);there was no statistical significance in PLT in groups B and C compared with that before blood transfusion(P＞0.05).After blood transfusion,Hb and PLT in groups B and C were higher than those in group A(P＜0.05),but there was no significant differ-ence between group B and group C(P＞0.05).After blood transfusion,thrombin time(TT),prothrombin time(PT)and activated partial thromboplastin time(APTT)in group A were significantly prolonged,D-dimer(D-D)and international nor-malized ratio(INR)were significantly increased,and fibrinogen(FIB)was significantly decreased(P＜0.05).There was no significant difference between group B and group C before transfusion(P＞0.05).After blood transfusion,TT,PT,APTT,D-D and INR in groups B and C were short or lower than those in group A,while FIB was higher than that in group A(P＜0.01),but there was no significant difference between group B and group C(P＞0.05).Conclusion SRBS︰FFP＜2︰1-1︰1 is an appropriate ratio for the treatment of acute massive traumatic hemorrhage,which can help to prevent co-agulation dysfunction and reduce the use of blood products.关键词
出血/创伤和损伤/悬浮红细胞/新鲜冰冻血浆/输血/配比/凝血酶时间/纤维蛋白原Key words
Hemorrhage/Wounds and injuries/Red blood cell suspension/Fresh frozen plasma/Blood transfusion/Ratio/Thrombin time/Fibrinogen分类
临床医学引用本文复制引用
余海燕,肖鑫,张黎,黄于庭..不同SRBS:FFP配比输注对急性创伤大出血患者凝血功能的影响[J].临床误诊误治,2023,36(9):38-42,5.基金项目
江苏省科技项目(BE2020720) （BE2020720）
安徽省高等学校科学研究项目(2022AH050791) （2022AH050791）
