皮肤性病诊疗学杂志2023，Vol.30Issue(6)：574-578,5.DOI:10.3969/j.issn.1674-8468.2023.06.017
线状IgA大疱性皮病的研究进展
Research progress on linear IgA bullous dermatosis
吴媚 1李德良 1司徒欣欣 1李国丽 1尹光文2
作者信息
- 1. 江门市新会区人民医院,广东 江门 529100
- 2. 郑州大学第一附属医院,河南 郑州 450052
- 折叠
摘要
Abstract
Linear IgA bullous dermatosis(LABD)is a rare autoimmune subepidermal blister-ing skin disease,manifested by erythematous plaques covered by circular blisters in a pattern of"string of pearls".Immune dysregulation and genetic factors are implicated in the onset of LABD.The pathogenesis includes abnormal deposition of IgA antibodies in the basement membrane zone and abnormal immune response.Although the pathological characteristics are atypical,direct im-munofluorescence shows deposition of linear IgA antibody at the basement membrane zone.Ad-vances in molecular biology and immunology offer new possibilities for enhancing precise diagno-sis.Personalized treatment has become pivotal,while topical steroids and antihistamines are suit-able for mild cases.Severe cases may require systemic immunosuppressants or even biologics.This review aims to summarize the latest research advances in LABD,including epidemiological features,pathogenesis,diagnostic and therapeutic strategies,and to provide an outlook on future research directions.关键词
线状IgA大疱性皮病/IgA抗体/免疫抑制剂Key words
linear IgA bullous dermatosis/IgA antibody/immunosuppressants引用本文复制引用
吴媚,李德良,司徒欣欣,李国丽,尹光文..线状IgA大疱性皮病的研究进展[J].皮肤性病诊疗学杂志,2023,30(6):574-578,5.
