临床误诊误治2023，Vol.36Issue(7)：78-81,4.DOI:10.3969/j.issn.1002-3429.2023.07.017
百令胶囊联合缬沙坦对维持性腹膜透析患者免疫功能、氧化应激指标及炎性因子的影响
Effects of Bailing Capsule Combined with Valsartan on Immune Function,Oxidative Stress Indexes and Inflammatory Factors in Patients Undergoing Maintenance Peritoneal Dialysis
摘要
Abstract
Objective To investigate the effects of Bailing capsule combined with Valsartan on immune function,oxi-dative stress indexes and inflammatory factors in chronic kidney disease(CKD)patients undergoing maintenance peritoneal di-alysis(MPD).Methods A total of 106 patients with stage 5 CKD who received MPD treatment from June 2020 to June 2022 were selected and divided into research group(n =53)and control group(n =53)according to different treatment methods.The research group was treated with Bailing capsule combined with Valsartan,and the control group was treated with Valsar-tan.Serum immune function,oxidative stress indexes and inflammatory factors were compared between the two groups before and at 8 weeks after treatment,as well as the occurrence of adverse reactions during treatment.Results At 8 weeks after treatment,serum CD4+,CD4+/CD8+,superoxide dismutase(SOD)and interleukin-2(IL-2)were higher than those be-fore treatment,and serum CD8+,malondialdehyde(MDA),reactive oxygen species(ROS),C reactive protein(CRP)and tumor necrosis factor-α(TNF-α)were lower than those before treatment.Serum CD4+,CD4+/CD8+,SOD and IL-2 in the research group were higher than those in the control group,while serum CD8+,MDA,ROS,CRP and TNF-α were lower than those in the control group(P＜0.01).During treatment,there was no significant difference in the total incidence of ad-verse reactions between the research group and the control group[7.55%(4/53)vs.11.32%(6/53),P＞0.05].Con-clusion Bailing capsule combined with Valsartan in the treatment of CKD patients undergoing MPD can improve immune function,reduce oxidative stress and inflammatory response,and has good safety.关键词
百令胶囊/缬沙坦/腹膜透析/慢性肾脏疾病/CD4+/CD8+/超氧化物歧化酶/白细胞介素-2Key words
Bailing capsule/Valsartan/Maintenance peritoneal dialysis/Chronic kidney disease/CD4+/CD8+/Superoxide dismutase/Interleukin-2分类
医药卫生引用本文复制引用
陈超,田璐,吴超然..百令胶囊联合缬沙坦对维持性腹膜透析患者免疫功能、氧化应激指标及炎性因子的影响[J].临床误诊误治,2023,36(7):78-81,4.基金项目
河北省卫生健康委基金项目(20191733) （20191733）
廊坊市科学技术研究与发展计划项目(2019013130) （2019013130）
