临床误诊误治2023，Vol.36Issue(7)：86-90,5.DOI:10.3969/j.issn.1002-3429.2023.07.019
非体外循环下冠状动脉旁路移植术后患者氧自由基、心肌损伤因子及炎性因子的变化
Changes in Oxygen Free Radicals,Myocardial Damage-related Factors and Inflammatory Factors in Patients after Off-pump Coronary Artery Bypass Transplantation
摘要
Abstract
Objective To investigate the changes of oxygen free radicals,myocardial damage-related factors and in-flammatory factors in patients after off-pump coronary artery bypass grafting(OPCABG).Methods In total,93 patients with coronary heart disease(CHD)treated from October 2019 to October 2022 were selected and divided into the OPCABG group(receiving OPCABG,n =51)and the on-pump coronary artery bypass grafting(CABG)group(receiving CABG,n =42)ac-cording to the surgical plan.The surgery-related factors,and the levels of serum oxygen free radicals,myocardial damage-related factors and inflammatory factors before and at 2,6 and 24 h after treatment were compared between the two groups.Results The duration of operation,length of ICU stay,duration of tracheal intubation,and length of hospitalization in the OPCABG group were shorter than those in the on-pump CABG group,and the blood transfusion volume at 24 h after operation was less than that in the on-pump CABG group(P＜0.01).After treatment,the level of superoxide dismutase(SOD)de-creased first and then increased,and the level of malondialdehyde(MDA)increased first and then decreased;the changes of SOD and MDA levels in OPCABG group were significantly smaller than those on-pump CABG group(P＜0.05,P＜0.01).With the extension of treatment time,the level of myocardial creatine kinase isoenzyme(CK-MB)in the two groups was grad-ually increased,and the level of CK-MB in OPCABG group was lower than that on-pump CABG group at 2,6 and 24 h after surgery(P＜0.05,P＜0.01).After treatment,the level of cardiac troponin I(cTnI)in the two groups increased initially and then decreased,and the cTnI level in the OPCABG group was lower than that on-pump CABG group at 2,6 and 24 h after surgery(P＜0.05,P＜0.01).With the prolongation of treatment,the levels of interleukin-6(IL-6),interleukin-8(IL-8)and interleukin-10(IL-10)in the two groups were gradually decreased,which were lower in OPCABG group than in on-pump CABG group at 2,6 and 24 h after surgery(P＜0.05,P＜0.01).Conclusion OPCABG can effectively reduce the levels of serum oxygen free radicals and inflammatory factors in patients with CHD,and can alleviate myocardial injury,which is bet-ter than that of on-pump CABG.关键词
冠心病/冠状动脉旁路移植术,非体外循环/超氧化物歧化酶/丙二醛/心肌型肌酸激酶同工酶/肌钙蛋白I/白细胞介素-6/白细胞介素-8Key words
Coronary heart disease/Coronary artery bypass grafting,off-pump/Superoxide dismutase/Malondialde-hyde/Myocardial creatine kinase isoenzyme/Troponin I/Interleukin-6/Interleukin-8分类
医药卫生引用本文复制引用
吴光航,吕晶,王俊华,李华军..非体外循环下冠状动脉旁路移植术后患者氧自由基、心肌损伤因子及炎性因子的变化[J].临床误诊误治,2023,36(7):86-90,5.基金项目
陕西省重点研发计划项目(2020SF-11321) （2020SF-11321）
