临床与实验病理学杂志2023，Vol.39Issue(12)：1487-1491,5.DOI:10.13315/j.cnki.cjcep.2023.12.015
INSM1在甲状腺髓样癌病理诊断中的意义
Significance of INSM1 in pathological diagnosis of medullary thyroid carcinoma
王雪寒 1郑燕军 2王小双 2刘琰 2蔡永萍3
作者信息
- 1. 安徽医科大学基础医学院病理教研室,合肥 230032||安徽医科大学附属宿州医院病理科,宿州 234000
- 2. 安徽医科大学附属宿州医院病理科,宿州 234000
- 3. 安徽医科大学基础医学院病理教研室,合肥 230032||安徽医科大学第一附属医院病理科,合肥 230022
- 折叠
摘要
Abstract
Purpose To explore the value of insulinoma associated protein 1(INSM1)in the pathological diagnosis and differential diagnosis of medullary thyroid carcinoma(MTC).Methods Twenty-eight cases of MTC were collected as the ex-perimental group and 25 cases of thyroid tumors(6 cases of transparent trabecular tumors,16 cases of poorly differentiated cancer,2 cases of spindle cell papillary carcinoma,and 1 case of thyroid paraganglioma)that needed to be differentiated from MTC in the same period were collected as the control group.The expression of INSM1 was detected using immunohistochemical EnVision method,and the sensitivity and specificity of INSM1 in MTC were analyzed,and compared with traditional MTC markers(Syn,CgA,CT,and CEA).Results The positive rate of IN-SM1 in the MTC group was96.4%(27/28),significantly high-er than the control group of 4.0%(1/25)(P<0.05).INSM1 had a sensitivity of 96.4%in MTC,significantly higher than CgA(71.4%)(P<0.05),and was positively expressed in CT negative MTC cases.The specificity of INSM1 in MTC was 96.0%,significantly higher than that of CEA(72.0%)(P<0.05).Conclusion INSM1 has high sensitivity and specificity in MTC,with a nuclear positive staining pattern,clear back-ground,and easy identification.It is superior to the traditional biomarkers and has high diagnostic value in MTC.关键词
甲状腺肿瘤/髓样癌/INSM1/鉴别诊断Key words
thyroid neoplasms/medullary thyroid carcinoma/INSM1/differential diagnosis分类
医药卫生引用本文复制引用
王雪寒,郑燕军,王小双,刘琰,蔡永萍..INSM1在甲状腺髓样癌病理诊断中的意义[J].临床与实验病理学杂志,2023,39(12):1487-1491,5.
