畜牧与饲料科学2023，Vol.44Issue(6)：82-87,6.DOI:10.12160/j.issn.1672-5190.2023.06.010
GnRH的生物学作用及其类似物在马属动物中的应用研究进展
Research Progress in Biological Roles of GnRH and Application of Its Analogues in Equine Animals
摘要
Abstract
The low reproductive rate is a bottleneck that restricts the development of the equine animal industry,and the inadequate technology for reproductive regulation is the primary cause for the slow growth of the industry.Gonadotropin-releasing hormone(GnRH),a neurohormone released by the hypothalamus,plays essential roles in the hypothalamic-pituitary-gonadal-axis pathway.GnRH can effectively promote follicular development and ovulation in equine animals.It is a decapeptide-containing compound that can be synthesized into many GnRH analogues by varying the amino acids at different locations within the decapeptide structure.GnRH and its analogues affect animal reproductive performance by stimulating the secretion of follicle-stimulating hormone(FSH)and luteinizing hormone(LH),and inhibiting the synthesis of estrogen receptors.It has been demonstrated that GnRH and its analogues could improve the reproductive performance of equine animals.This article reviews the structural characteristics and biological functions of GnRH and gonadotropin-releasing hormone receptor(GnRHR)as well as the research progress in the application of GnRH analogues in the reproduction of equine animals,in hoping to provide references for exploring the molecular mechanisms behind the biological effects of GnRH and the scientific application of GnRH analogues in the reproductive regulation of equine animals.关键词
促性腺激素释放激素/促性腺激素释放激素受体/促性腺激素释放激素类似物/生物学功能/马属动物/繁殖调控Key words
gonadotropin-releasing hormone/gonadotropin-releasing hormone receptor/gonadotropin-releasing hormone analogue/biological function/equine animal/reproductive regulation分类
农业科技引用本文复制引用
李泽廷,苏少锋,赵俊利,孙培陪,白晋宇,吴海青..GnRH的生物学作用及其类似物在马属动物中的应用研究进展[J].畜牧与饲料科学,2023,44(6):82-87,6.基金项目
内蒙古自治区呼和浩特市重大科技项目"驴高效繁殖技术研究与示范"(2020-农-重-2) （2020-农-重-2）
内蒙古自治区农牧业创新基金项目"牛羊品种育繁技术研究与示范——基于GEBV技术的乳用驴核心群建立及选育技术研究(2022CXJJM02)". （2022CXJJM02）
