老年医学与保健2023，Vol.29Issue(6)：1129-1133,5.
老年肺腺癌手术患者程序性死亡受体配体1表达及临床病理意义和预后分析
Expression of programmed death receptor ligand 1 in elderly patients undergoing surgery for lung adenocarcinoma and analy-sis of its clinicopathological significance and prognosis
摘要
Abstract
Objective To investigate the expression of programmed death receptor ligand 1(PD-L1)and its clinico-pathological significance and prognosis in elderly patients undergoing surgery for lung adenocarcinoma.Methods The data of 70 elderly patients with lung adenocarcinoma who underwent surgery in Department of Thoracic Surgery of Huadong Hospital Affiliated to Fudan University from January 2021 to August 2021 were retrospectively analyzed.According to PD-L1 expres-sion,they were divided into PD-L1 positive group(n =28)and PD-L1 negative group(n =42).Age,gender,smoking histo-ry,tumor stage,T stage,N stage,pleural invasion,tumor size,preoperative serum carcinoembryonic antigen level,tumor dif-ferentiation degree and vascular tumor thrombus status were compared between the two groups.The impacts of different clinico-pathological features on the prognosis of patients were analyzed.Results Compared with the PD-L1 negative group,there were more male patients in the PD-L1 positive group,worse tumor stage and N stage,poorer tumor differentiation degree,and higher incidence of vascular cancer thrombus,with statistical significances(P＜0.05).Among 70 elderly patients with lung adenocarcinoma,17 died and 53 survived,with a survival rate of 75.71%(53/70).The patients with PD-L1 positive expres-sion,stage Ⅲ and above,and poor differentiation had a poorer prognosis(P＜0.05).Conclusion The expression of PD-L1 is to some extent related to tumor stage,N-stage,differentiation degree,vascular cancer thrombus and gender.The elderly pa-tients with PD-L1 positive expression may have a poor prognosis.关键词
老年/肺腺癌/程序性死亡受体配体1/预后Key words
elderly/lung adenocarcinoma/programmed death receptor ligand 1/prognosis引用本文复制引用
李政,姚源山,高文..老年肺腺癌手术患者程序性死亡受体配体1表达及临床病理意义和预后分析[J].老年医学与保健,2023,29(6):1129-1133,5.基金项目
国家自然科学基金面上项目(62176063) （62176063）
科技部政府间国际科技创新合作项目(2019YFE0105600) （2019YFE0105600）
