昆明医科大学学报2023，Vol.44Issue(12)：1-5,5.DOI:10.12259/j.issn.2095-610X.S20231231
玫瑰石斛的化学成分及其生物活性
Chemical Compounds Isolated from Dendrobium crepidatum and Their Bioactive Activities
摘要
Abstract
Objective To study the chemical constituents from the herbs of Dendrobium crepidatum and identify its antitumor bioactive compounds.Methods The constituents were extracted by methyl alcohol and isolated by CC and Sephadex LH-20.Their structures were identified by spectroscopic analysis(1H NMR,13CNMR and EIMS).The antitumor activity of the constituents was determined by MTT assay in vitro.Results 9 compouds were obtained and identified as p-hydroxybenzaldehyde(1),p-methoxyphenol(2),p-Hydroxybenzyl alcohol(3),hydroquinone(4),(24R)-ethylcholest-5-en-3-ol-7-one(5),sinalexin(6),bis(2-ethylhexyl)benzene-1,2-dicarboxylate(7),pinoresinol(8),Chaenomin B(9).The antitumor activity of compounds 5～9 was tested,and it was found that compound 9 had good inhibitory activity against A549 cell line.Conclusion Compounds 2～5,7～8 were isolated from the herbs for the first time and compounds 6,9 were isolated from this genus for the first time.IC50 of 9 on A549 cell line is 29.35 µM.关键词
玫瑰石斛/化学成分/生物活性Key words
Dendrobium crepidatum/Chemical constituents/Bioactive activity分类
医药卫生引用本文复制引用
庄晨曦,王慧敏,陈亚萍,张锐,郑金蓉,李美红,李玉鹏..玫瑰石斛的化学成分及其生物活性[J].昆明医科大学学报,2023,44(12):1-5,5.基金项目
国家自然科学基金资助项目(21202066) （21202066）
云南省科技厅-昆明医科大学联合专项基金资助项目(202301AY070001-212) （202301AY070001-212）
云南省本科教育教学改革研究基金资助项目(JG2023001) （JG2023001）
昆明医科大学教研教改基金资助项目(2022-JY-S-08) （2022-JY-S-08）
云南省创新团队基金资助项目(202005AE160004) （202005AE160004）
云南省天然药物药理重点实验室开放研究基金资助项目(YKLPNP-G2407) （YKLPNP-G2407）
