临床输血与检验2023，Vol.25Issue(6)：733-738,6.DOI:10.3969/j.issn.1671-2587.2023.06.003
改进后大量输血策略在原位肝移植手术中的应用研究
Evaluation of an Improved Massive Transfusion Protocol in Orthotopic Liver Transplantation
朱海洋 1贺理 2王勇军2
作者信息
- 1. 中南大学湘雅二医院输血科,湖南长沙 410011||张家界市人民医院输血科,湖南张家界 427000
- 2. 中南大学湘雅二医院输血科,湖南长沙 410011
- 折叠
摘要
Abstract
Objective To evaluate an improved massive transfusion protocol(MTP)to reduce transfusion and complications in orthotopic liver transplantation(OLT)at a single institution.Methods We retrospectively studied the massive ransfusion patients who underwent OLT at the Second Xiangya Hospital of Central South University from January 2016 to December 2022,enrolled 146 baseline data-matched cases(73 in improved MTP group and 73 in initial MTP group)by propensity-matched analysis,and compared the intraoperative transfusion profiles,laboratory and clinical outcomes and prognosis.Results Improved MTP decreased the intraoperative erythrocyte transfusion,increased apheresis platelet and cryoprecipitate transfusion,and plasma/platelet to red blood cell(RBC)transfusion ratios(P＜0.05),but there was no statistically significant difference in plasma transfusion between the two groups(P＞0.05).In improved MTP group,the level of Hb,PLT,FIB and TT were significantly increased(P＜0.05),PT was significantly decreased(P＜0.05),the renal markers(CREA and UREA)elevated values and in-hospital mortality rate were significantly lower(P＜0.05).Conclusion In OLT,the improved MTP can reduce unnecessary blood transfusion and improve transfusion efficacy.关键词
原位肝移植术/大量输血策略/输血安全/倾向性匹配Key words
Orthotopic liver transplantation/Massive transfusion protocol/Transfusion safety/Propensity matching分类
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朱海洋,贺理,王勇军..改进后大量输血策略在原位肝移植手术中的应用研究[J].临床输血与检验,2023,25(6):733-738,6.
