昆明医科大学学报2023，Vol.44Issue(12)：87-94,8.DOI:10.12259/j.issn.2095-610X.S20231214
奥密克戎变异株老年重症感染者细胞免疫指标对预后的价值研究
A Study on Prognostic Value of Cellular Immunological Indicators in Omicron Variant Infected Elderly Severe Patients
摘要
Abstract
Objective To investigate the characteristics of clinical cellular immunity and its relationship with prognosis in elderly patients with severe infection caused by Omicron variant.Methods The clinical data of 53 patients with Omicron variant infection admitted to the geriatric Intensive Care Unit of the First Affiliated Hospital of Kunming Medical University from December 2022 to February 2023 were retrospectively analyzed.The patients were divided into 22 survival cases and 31 death cases for comparison between the two groups.Logistic analysis is adopted to define the omicron variants of elderly severe infections prognostic factors and construct the ROC curve.Results Mu-ltivariate logistic analysis revealed that the independent risk factors were elevated IL-6(P = 0.043)and decreased absolute T lymphocyte count(P = 0.011).AUC value of ROC of IL-6,absolute T lymphocyte count and IL-6 combined with absolute T lymphocyte count was 0.818,0.796 and 0.887.Conclusion Elevated IL-6 and decreased absolute T lymphocyte count are independent risk factors for elderly severe patients with Omicron variant infections.关键词
奥密克戎变异株/预后/细胞免疫Key words
Omicron variant/Prognosis/Cellular immunological indicators分类
医药卫生引用本文复制引用
唐杰夫,杨德兴,刘圣哲,王强,付凯,王振方,栾英,李敏,刘荣..奥密克戎变异株老年重症感染者细胞免疫指标对预后的价值研究[J].昆明医科大学学报,2023,44(12):87-94,8.基金项目
云南省老年疾病临床研究中心-老年共病诊疗及临床转化研究基金资助项目(202102AA310069) （202102AA310069）
昆明医科大学研究生创新基金资助项目(2023S245) （2023S245）
