昆明医科大学学报2023，Vol.44Issue(12)：139-143,5.DOI:10.12259/j.issn.2095-610X.S20231222
EV71阳性手足口病患儿131例临床特征及其EV71疫苗接种的预防效果
Clinical Characteristics of 131 Children with Hand,Foot,and Mouth Disease Infected with EV71 and Preventive Effect of EV71 Vaccination
摘要
Abstract
Objective To analyze the clinical features of children with EV71 positive hand,foot,and mouth disease(HFMD)and EV71 vaccination,and to explore the relationship between the occurrence of severe disease and the preventive effect of EV71 vaccine.Methods From January 1,2020 to December 31,2022,the clinical data of 131 children with HFMD diagnosed with EV71 infection in Kunming Children's Hospital were retrospectively analyzed.The stool samples of patients with clinically confirmed HFMD were selected for enterovirus nucleic acid detection.The clinical data and EV71 vaccination status of children with universal enterovirus positive and EV71 positive HFMD were analyzed.Results Among the 131 positive cases detected,there were 116 mild cases and 15 severe cases.Among the 80 children who received phone consultations about their EV71 vaccine status,17 were vaccinated,and 63 were not vaccinated.The vaccinated children were all mild cases,while among the unvaccinated children,6 were severe cases.From 2020 to 2022,the period from April to September each year is the peak period for detecting EV71-positive hand,foot,and mouth disease(χ2 = 125.705,P = 0.000).The positive detection rate for children under 1 year old and over 5 years old was higher than that for children aged 1 to 5 years(χ2 = 8.765,P = 0.033),and there was no significant difference in the positive detection rate between boys and girls(χ2 = 1.221,P = 0.269).Conclusion EV71 vaccine is of great significance in reducing the occurrence of severe cases.Combined with the current low vaccination rate in Kunming,Yunnan Province,it is suggested that relevant institutions should continue to increase the publicity of EV71 vaccination.关键词
EV71阳性/手足口病/EV71疫苗Key words
EV71 positive/Hand foot,and mouth disease/EV71 vaccine分类
医药卫生引用本文复制引用
宋顺琪,蒋鸿超,马云超,冯星星,杜廷义,张红芳..EV71阳性手足口病患儿131例临床特征及其EV71疫苗接种的预防效果[J].昆明医科大学学报,2023,44(12):139-143,5.基金项目
昆明市卫生健康委员会卫生科研课题基金资助项目(2022-11-01-008) （2022-11-01-008）
昆明市儿童新发及诊断未明感染性疾病病原鉴定及致病机理医学研究机构(2023-SW研-02) （2023-SW研-02）
