药学研究2023，Vol.42Issue(12)：1016-1021,1056,7.DOI:10.13506/j.cnki.jpr.2023.12.012
选择性剪接在肿瘤化疗耐药中的研究进展
Research progress of alternative splicing in tumor chemotherapy resistance
摘要
Abstract
Malignant tumor is one of the major diseases threatening human health.The resistance of tumor cells to chemical drugs is an important reason for the failure of chemotherapy.The mechanisms of chemotherapy resistance in tumor cells are complex,and many of them involve mutations and expression changes of genes and proteins.Recently,alternative splicing isomers have been found to be one of the new mechanisms leading to chemotherapy resistance in tumors.In order to fully understand the impact of alternative splicing on cancer biology and treatment development,we summarized the role of alternative splicing in regulating the acquisition of chemotherapy resistance in cancer cells,and analyzed and summarized these molecular regulatory splicing events to provide new ideas for coping with tumor chemotherapy resistance.关键词
选择性剪接/剪接体/化疗耐药Key words
Alternative splicing/Spliceosome/Chemotherapy resistance分类
临床医学引用本文复制引用
苗春萌,吴启鹏,江振洲,张陆勇..选择性剪接在肿瘤化疗耐药中的研究进展[J].药学研究,2023,42(12):1016-1021,1056,7.基金项目
双一流团队"药物安全预警关键技术研究创新团队"项目资助(No.CPU2018GY33) （No.CPU2018GY33）
江苏省研究生科研与实践创新计划(No.KYCX20_0666) （No.KYCX20_0666）
