中国海洋大学学报（自然科学版）2024，Vol.54Issue(2)：106-113,8.DOI:10.16441/j.cnki.hdxb.20220472
小檗碱衍生物的合成及抗菌活性研究
Synthesis and Antibacterial Activity of Berberine Derivatives
摘要
Abstract
Berberine has broad-spectrum antibacterial activity,but its antibacterial effect is not very good.The structure of berberine was modified to obtain berberine derivatives with higher antibacterial activity.The active benzothiazoles of PC190723 derivatives,a classical FtsZ inhibitor,were introduced into berberine,and the structure of berberine was modified and its antibacterial activity was tested in vitro.Ten berberine derivatives were synthesized,among which 5 compounds showed significantly bet-ter antibacterial activity against Staphylococcus aureus and methicillin-resistant Staphylococcus aureus.关键词
小檗碱/苯并噻唑/FtsZ抑制剂/结构改造/抗菌活性Key words
berberine/benzothiazole/ftsz inhibitor/structural modification/antibacterial activity分类
医药卫生引用本文复制引用
葛莲,程珊,吕钦,万升标..小檗碱衍生物的合成及抗菌活性研究[J].中国海洋大学学报（自然科学版）,2024,54(2):106-113,8.基金项目
国家自然科学基金项目(81973170)资助Supported by the National Natural Science Foundation of China(81973170) （81973170）
