青岛大学学报（医学版）2023，Vol.59Issue(6)：821-825,5.DOI:10.11712/jms.2096-5532.2023.59.176
术前外周血炎症指标对转移性肾癌的预后价值
PROGNOSTIC VALUE OF PREOPERATIVE PERIPHERAL BLOOD INFLAMMATORY MARKERS FOR METASTATIC RENAL CELL CARCINOMA
摘要
Abstract
Objective To explore the prognostic value of the platelet-to-lymphocyte ratio(PLR),neutrophil-to-lympho-cyte ratio(NLR),and systemic immune-inflammation index(SII)in patients with metastatic renal cell carcinoma(MRCC)under-going cytoreductive surgery.Methods We retrospectively analyzed the clinical data of 80 patients diagnosed with MRCC under-going cytoreductive surgery in the Department of Urology of The Affiliated Hospital of Qingdao University from January 2012 to December 2016.Using X-tile 3.6.1 software,the optimal cut-off values of the peripheral blood inflammatory markers were deter-mined to divide the patients into high-level and low-level groups for comparison analysis.Univariable and multivariable Cox regres-sion analyses were performed to determine the influence of inflammatory indicators and other clinicopathological features on patient prognosis.Results The optimal cut-off values of NLR,PLR,and SII were 2.7,161.0,and 734.1,respectively.High NLR,PLR,and SII values were all significantly associated with a worse Fuhrman grade(χ2=4.863-17.875,P<0.05).The univariable analysis showed that Fuhrman grade(χ2=6.045,P=0.014),T stage(χ2 =3.969,P=0.046),being clear cell carcinoma or not(χ2=9.743,P=0.002),NLR(χ2=17.025,P<0.001),PLR(χ2=8.441,P=0.004),and SII(χ2=44.345,P<0.001)were in-fluencing factors for the overall survival(OS)of patients with MRCC undergoing cytoreductive surgery.The multivariable Cox re-gression analysis showed that SII(HR=5.087,95%CI=2.218-11.665,P<0.05),Fuhrman grade(HR=1.684,95%CI= 1.019-2.782,P<0.05),and being clear cell carcinoma or not(HR=0.487,95%CI=0.258-0.918,P<0.05)were independent factors affecting the OS of the patients.Conclusion Preoperative high levels of SII suggest a poor survival outcome in patients with MRCC undergoing cytoreductive surgery.关键词
癌,肾细胞/肿瘤转移/血小板计数/淋巴细胞计数/中性粒细胞计数/系统免疫炎症指数/预后Key words
carcinoma,renal cell/neoplasm metastasis/platelet count/lymphocyte count/absolute neutrophil count/systemic immune-inflammation index/prognosis分类
医药卫生引用本文复制引用
李翔宇,毛昕,张庆松,裴兴超..术前外周血炎症指标对转移性肾癌的预后价值[J].青岛大学学报（医学版）,2023,59(6):821-825,5.基金项目
国家自然科学基金资助项目(82100285) （82100285）
