青岛大学学报（医学版）2023，Vol.59Issue(6)：832-834,3.DOI:10.11712/jms.2096-5532.2023.59.100
Apo D对多巴胺能神经元Basigin表达影响
EFFECT OF APOLIPOPROTEIN D ON THE PROTEIN EXPRESSION OF BASIGIN IN DOPAMINERGIC NEURONS
摘要
Abstract
Objective To investigate the effect of apolipoprotein D(Apo D)on the protein expression of Basigin(BSG)in dopaminergic neurons.Methods Stainless steel tubes were placed in the lateral ventricle of mice,followed by the treatment with exogenous Apo D.Mouse dopaminergic neurons MES23.5 cells were cultured and treated with exogenous Apo D.Western Blotting was used to measure the change in the protein expression of BSG in the substantia nigra and MES23.5 cells.Results Compared with the control group,the exogenous Apo D group had a significant increase in the protein expression level of BSG in both neurons in the substantia nigra and MES23.5 cells(t=2.299,3.408;P<0.05).Conclusion Exogenous Apo D can promote the protein expression of BSG in dopaminergic neurons.关键词
载脂蛋白D类/Basigin/多巴胺能神经元Key words
apolipoproteins D/Basigin/dopaminergic neuron分类
医药卫生引用本文复制引用
栾梦瑶,阎春玲,姜宏..Apo D对多巴胺能神经元Basigin表达影响[J].青岛大学学报（医学版）,2023,59(6):832-834,3.基金项目
山东省重点研发计划(重大科技创新工程)项目(2021ZDSYS11) （重大科技创新工程）
