青岛大学学报（医学版）2023，Vol.59Issue(6)：845-849,5.DOI:10.11712/jms.2096-5532.2023.59.191
尿蛋白与肌酐比值在妊娠期高血压疾病中应用价值
APPLICATION VALUE OF URINE ALBUMIN-TO-CREATININE RATIO IN HYPERTENSIVE DISORDERS OF PREGNANCY
摘要
Abstract
Objective To investigate the correlation between the urine albumin-to-creatinine ratio(ACR)and clinical pa-rameters in patients with hypertensive disorders of pregnancy(HDP),and to explore the clinical significance of ACR in assessing impairment in renal function.Methods We included a total of 225 pregnant women with different types of HDP who received regular prenatal examinations at The Affiliated Hospital of Qingdao University from May 2018 to October 2019,including 55 with gestational hypertension,89 with preeclampsia,4 with eclampsia,40 with chronic hypertension,and 37 with chronic hypertension with superimposed preeclampsia.A total of 60 normal pregnant women with a single fetus examined at the same hospital during the same period were randomly selected as the control group.All the subjects had ACR,routine blood,routine coagulation,routine urine,liver and kidney function,and blood lipid tests.Patients with abnormal urine protein levels received 24 h urine protein mea-surement.Results ACR was highly linearly correlated with 24 h urine protein level(r=0.800,P<0.05),positively correlated with diastolic blood pressure,uric acid,UREA,and lactate dehydrogenase(r=0.484-0.574,P<0.05),and negatively correlated with albumin(r=-0.579,P<0.05).For ACR plus uric acid diagnosing renal impairment in pregnant women with HDP,the area under the receiver operating characteristic curve was 0.996,the cut-off value was 0.881,the specificity was 0.951,and the sensiti-vity was 0.929.Conclusion ACR is associated with increased diastolic blood pressure,uric acid,UREA,and lactate dehydro-genase levels and decreased albumin levels.The highly linear correlation between ACR and 24 h urine protein level indicates that ACR is an accurate and convenient indicator for the diagnosis of HDP.ACR and uric acid levels increase with the severity of HDP,and their combination has clinical value in evaluating renal injury in pregnant women with HDP.关键词
高血压,妊娠性/白蛋白尿/肌酸酐/尿分析/诊断Key words
hypertension,pregnancy-induced/albuminuria/creatinine/urinalysis/diagnosis分类
医药卫生引用本文复制引用
陈响,詹瑛,卢彩霞,郑富民,刘世国..尿蛋白与肌酐比值在妊娠期高血压疾病中应用价值[J].青岛大学学报（医学版）,2023,59(6):845-849,5.基金项目
山东省自然科学基金资助项目(ZR2019MH127) （ZR2019MH127）
