青岛大学学报（医学版）2023，Vol.59Issue(6)：855-859,5.DOI:10.11712/jms.2096-5532.2022.59.197
血浆维生素B12与阿尔茨海默病脑脊液的相关性
ASSOCIATION BETWEEN PLASMA VITAMIN B12 AND CEREBROSPINAL FLUID BIOMARKERS FOR ALZHEIMER’S DISEASE
摘要
Abstract
Objective To investigate the association between plasma vitamin B12 concentration and cerebrospinal fluid biomarkers for Alzheimer’s disease(AD)in the non-dementia population.Methods A total of 539 non-dementia subjects were selected from the Alzheimer’s Disease Neuroimaging Initiative database(http://adni.loni.usc.edu)and were then divided into mild cognitive impairment(MCI)group and cognitively normal(CN)group.A multiple linear regression model was established for the adjustment of age,sex,educational level,apolipoprotein E genotype,hypertension,diabetes,hyperlipidemia,smoking,and drinking,and the association of plasma vitamin B12 concentration with cerebrospinal fluid biomarkers(tau protein(tau)and phos-phorylated tau protein(p-tau))for AD was analyzed in the non-dementia population and the two subgroups.Results In the non-dementia population,plasma vitamin B12 concentration was significantly negatively correlated with tau(β=-1.227e-04,P<0.05)and p-tau(β=-4.575e-05,P<0.05).The subgroup analysis showed that in the MCI group,plasma vitamin B12 concentration was significantly negatively correlated with tau(β=-1.688e-04,P<0.05)and p-tau(β=-1.718e-04,P<0.05),while in the CN group,plasma vitamin B12 concentration was not significantly correlated with tau(β=-5.983e-06,P>0.05)or p-tau(β=-2.375e-05,P>0.05).Conclusion Plasma vitamin B12 concentration is significantly correlated with the cerebrospinal fluid biomarkers tau and p-tau for AD in the non-dementia population.关键词
维生素B12/阿尔茨海默病/认知功能障碍/生物标记Key words
vitamin B12/Alzheimer disease/cognitive dysfunction/biomarkers分类
医药卫生引用本文复制引用
彭艳,赵冰,李鑫,王皓,张伟..血浆维生素B12与阿尔茨海默病脑脊液的相关性[J].青岛大学学报（医学版）,2023,59(6):855-859,5.基金项目
山东省泰山学者计划项目(ts201511109) （ts201511109）
