陕西中医2024，Vol.45Issue(1)：13-16,22,5.DOI:10.3969/j.issn.1000-7369.2024.01.003
解毒活血汤对慢性肾脏病大鼠肾脏FGF23、Klotho表达的影响
Effects of Jiedu Huoxue decoction on the expression of FGF23 and Klotho in the kidneys of rats with chronic kidney disease
摘要
Abstract
Objective:To observe the effects of Jiedu Huoxue decoction on FGF23 and Klotho in rats with chron-ic kidney disease(CKD).Methods:Sixty healthy male SD rats with SPF grade were randomly divided into black group A,group B,group I,group H,and group G,with 12 rats in each group.A model of vascular calcification in rats with CKD was prepared using adenine plus high-phosphorus diet.Biochemical kits were used to determine Scr,BUN,Ca,P levels.The Western blot method detected the expression of FGF23,Klotho in kidney tissue.Results:Compared with the blank group,the serum serum Scr,BUN,Ca and P were significantly changed in the rest groups(P<0.05 or P<0.01).In compared to the model group,the serum levels of Scr,BUN and P in group G,group H and group I were significantly improved(P<0.05),the expression of FGF23 and Klotho proteins was increased(P<0.05),and the serum Ca level was increased(P<0.05).Conclusion:Jiedu Huoxue decoction can improve the kidney function of CKD rats,and can affect the unbalanced FGF23-Klotho axis by increasing the expression of FGF23 and Klotho pro-teins in the kidney tissues of CKD rats,and then regulate the concentration of Ca and P in the blood of CKD rats.关键词
慢性肾脏病/解毒活血汤/去菀陈莝/成纤维细胞生长因子23/Klotho蛋白/大鼠Key words
Chronic kidney disease/Jiedu Huoxue decoction/Quwan Chencuo/FGF23/Klotho/Rats分类
医药卫生引用本文复制引用
周鹏,孙妲男,李勇,徐丽,乔伟..解毒活血汤对慢性肾脏病大鼠肾脏FGF23、Klotho表达的影响[J].陕西中医,2024,45(1):13-16,22,5.基金项目
黑龙江省自然科学基金资助项目(LH2021H086) （LH2021H086）
黑龙江省中医药科研项目(ZHY2020-139,ZHY2022-176) （ZHY2020-139,ZHY2022-176）
黑龙江省博士后研究人员落户黑龙江科研启动金资助项目(LBH-Q21190) （LBH-Q21190）
