补肾化痰汤联合来曲唑治疗多囊卵巢综合征临床研究OACSTPCD

Objective:To study effect of Bushen Huatan decoction combined with letrozole in the treatment of polycystic ovary syndrome and its influence on Fibroblast growth factor 21(FGF-21),growth hormone releasing peptide(Ghrelin)and endocrine.Methods:200 patients with polycystic ovary syndrome(PCOS)were divided into experimental group and control group(100 cases each group)by random number table method.The control group was given letrozole treatment,and the experimental group was given Bushen Huatan decoction on the basis of the control group.The clinical efficacy,FGF-21,Ghrelin,endocrine and ovarian function changes and the occurrence of adverse reactions were compared between the two group.Results:After treatment,was significantly different(P<0.05).After treatment,FGF-21 level was decreased in both groups,the decrease was more obvious in experimental group,the Ghrelin level was increased,the increase was more obvious in experimental group(P<0.05).After treat-ment,LH levels were decreased in both groups,and the levels of FSH and E2 were increased(P<0.05).After treat-ment,the ovarian volume,follicle number and resistance index were decreased in both groups,the decrease was more obvious in experimental group,and the pulsation index was increased,and the increase was more obvious in experi-mental group(P<0.05).During treatment,the main adverse reactions were nausea and vomiting,abdominal discom-fort and increased menstrual volume,and the incidence of the two groups was compared(P>0.05).Conclusion:Bushen Huatan decoction combined with letrozole has a remarkable effect in the treatment of polycystic ovary syn-drome,which may be related to the effective improvement of FGF-21,Ghrelin and endocrine levels in patients.