陕西中医2024，Vol.45Issue(1)：55-58,66,5.DOI:10.3969/j.issn.1000-7369.2024.01.012
急性缺血性脑卒中中医常见证型血清学相关指标变化临床研究
A clinical study on the changes of serological indexes of Chinese medicine commonly witnessed in acute ischemic stroke
摘要
Abstract
Objective:To explore the changes of serum NT-ProBNP,CRP,Fib and Hcy of TCM common wit-ness type in acute ischemic stroke,and analyze the clinical significance.Methods:A total of 110 patients with acute is-chemic stroke(AIS)were selected and divided into four common witness types according to the"Ischemic Stroke Syndrome Elements Diagnostic Scale".Clinical data of all subjects were collected after admission,fasting venous blood was collected,and the levels of NT-ProBNP,homocysteine(Hcy),C-reactive protein(CRP)and fibrinogen(Fib)were determined.The differences of the above levels in patients with different syndrome types and the control group were compared.Results:After analysis,NT-ProBNP level among the syndrome:wind phlegm-stasis syndrome>wind phlegm-fire hyperactivity syndrome,Qi deficiency and blood stasis syndrome,phlegm-heat fu-organs demonstration(all P<0.05).Evidence of hyperactivity of wind phlegm and fire>phlegm-heat fu organs(all P<0.05),there was no difference among the other syndroms(P>0.05).The Fib level among all syndroms:wind phlegm-stasis syndrome>Qi deficiency and blood stasis syndrome,phlegm-heat fu-organs(all P<0.05).Syndrome of hyperactivity of wind phlegm and fire>phlegm-heat fu organs(P<0.05),there was no difference among the other syndroms(P>0.05).The levels of Hcy and CRP among all syndroms were:phlegm-heat fu-organs>syndrome of wind-phlegm-stasis>syndrome of qi deficiency and blood-stasis>syndrome of wind-phlegm-fire hyperactivity,with statistical difference(all P<0.05).There was no significant difference in the abnormal rate of serological indexes among the four syndrome types(P>0.05).The syndrome of wind-phlegm-fire hyperactivity is closely related to hypertension,NT-ProBNP,CRP and Hcy.Qi deficiency and blood stasis syn-drome is closely related to Fib.The syndrome of wind-phlegm-stasis is closely related to NT-ProBNP,coronary heart dis-ease,Fib and Hcy.The phlegm-heat fu-organs were closely related to CRP and Hcy(P<0.05).Conclusion:Among the AIS syndrome types,the proportion of patients with wind-phlegm-stasis syndrome was the highest,and the proportion of patients with phlegm-heat fu-organ syndrome was the least.The risk factors of wind-phlegm-fire hyperactivity syndrome were NT-ProBNP,coronary heart disease,Fib and Hcy.The risk factors of phlegm-heat syndrome were CRP and Hcy.The risk factors of Qi deficiency and blood stasis syndrome were Fib.The risk factors of wind-phlegm-blood stasis syndrome were NT-ProBNP,coronary heart disease,Fib and Hcy.关键词
急性缺血性脑中风/辨证分型/血清N末端前脑钠肽/C反应蛋白/纤维蛋白原/同型半胱氨酸Key words
Acute ischemic cerebral stroke/Syndrome differentiation and classification/N-terminal pro-brain natri-uretic peptide/C-reactive protein/Fibrinogen/Homocysteine分类
医药卫生引用本文复制引用
杨泳,杨惠卿..急性缺血性脑卒中中医常见证型血清学相关指标变化临床研究[J].陕西中医,2024,45(1):55-58,66,5.基金项目
北京市卫生与健康科技成果和适宜技术推广项目(2018-TG-68) （2018-TG-68）
