陕西中医2024，Vol.45Issue(1)：67-70,4.DOI:10.3969/j.issn.1000-7369.2024.01.015
桂枝芍药知母汤治疗痛风性关节炎急性期疗效及对患者可调节相关因子与嘌呤受体水平变化的影响
Study on the changes of regulating related factors and purine receptors in the treatment of gouty arthritis by Guizhi Shaoyao Zhimu decoction
摘要
Abstract
Objective:To observe the effect of Guizhi Shaoyao Zhimu decoction combined with colchicine and celecoxib in treating acute stage of gouty arthritis,and to provide reference for clinical treatment.Methods:110 pa-tients with gout arthritis in the acute stage were randomly divided into a conventional group(treated with western medicine)and a decoction group(treated with western medicine+ Guizhi Shaoyao Zhimu decoction),with 55 pa-tients in each group.Recorded the changes in the levels of blood uric acid(UA),sedimentation(ESR),interleukin-1β(IL-1β),interleukin-18(IL-18),Diekkopf-1(DKK-1),purinergic receptor(P2 X7 R)and TCM syndrome score before and after 3 d and 7 d,efficacy and adverse effects included in group 2 were calculated,and TCM syndrome score were calculated.Results:After 7 days of treatment,the total effective rate of the observation group was 90.91%(50/55),which was significantly higher than that of the control group 76.36%(42/55),with statistical significance(P<0.05).After 3 and 7 days of treatment,skin color skin temperature,systemic symptoms and joint related scores in both groups were lower than before treatment,the observation group was lower than the control group,and the two groups were lower than after 7 days of treatment(P<0.05).After 3 and 7 days of treatment,UA,IL-1β,DKK-1,IL-18,P2 X7 R and ESR in both groups were lower than before treatment,the observation group was lower than the control group,and the above factors were lower after 7 days of treatment than after 3 days of treatment(P<0.05).The incidence of adverse reactions in the observation group was 9.09%(1 case of chest tightness and 4 cases of gas-trointestinal symptoms),compared with 20.00%(2 cases of chest tightness,8 cases of gastrointestinal symptoms and 1 case of rash)in the control group,there was no statistical significance(P>0.05).Conclusion:Guizhi Shaoyao Zhimu decoction combined with western medicine in the treatment of acute gouty arthritis can reduce symptoms and improve the curative effect,which may be related to regulating the expression levels of related factors.关键词
痛风性关节炎急性期/桂枝芍药知母汤/非布司他/塞来昔布/血尿酸/血沉Key words
Acute states of gouty arthritis/Guizhi Shaoyao Zhimu decoction/Colchicine/Celecoxib/Blood uric acid/Sedimentation分类
医药卫生引用本文复制引用
戴政文,钟传棋,杨志新..桂枝芍药知母汤治疗痛风性关节炎急性期疗效及对患者可调节相关因子与嘌呤受体水平变化的影响[J].陕西中医,2024,45(1):67-70,4.基金项目
湖北省中医药中西医结合科研项目[鄂卫生计生通(2017)20号] （2017）
