四川中医2023，Vol.41Issue(10)：136-140,5.
化湿泻浊方辨证加减治疗糖尿病肾病(DKD)上焦湿热证的效果及对炎症反应的影响
Effect of dialectical addition and subtraction of Huashi Xiezhuo Recipe on damp heat syndrome of upper energizer in diabetes nephropathy(DKD)and its influence on inflammatory reaction
摘要
Abstract
ObjectiveTo study the effect of dialectical addition and subtraction of Huashi Xiuzhuo decoction in the treatment of upper energizer dampness-heat syndrome of diabetic kidney disease(DKD)and its influence on inflammatory response.Meth-ods 94 patients with DKD in the hospital from October 2021 to October 2022 were selected as the samples,and were divided into observation group and control group with 47 cases in each group by the random number table method for prospective control study.Both groups were given individualized hypoglycemic,hypohypertensive,hypolipidemic and other basic treatments according to the guidelines,and the observation group was additionally treated with addition and subtraction of Huashi Xiuzhuo decoction.Both groups were treated for 3 courses by taking 4 weeks as 1 course of treatment.The clinical efficacy,TCM syndromes scores,blood glucose,renal function and inflammatory factors were compared between both groups.Results The effective rates in observation group and control group at 3 courses of treatment were 89.36％and 72.34％(P＜0.05).After treatment,the scores of primary and secondary symptoms of upper energizer dampness-heat syndrome in both groups were significantly decreased(P＜0.05),and the scores were lower in observation group than those in control group(P＜0.05).Fasting plasma glucose(FPG),2 h postpran-dial plasma glucose(2 hPG)and glycosylated hemoglobin(HbA1c)were significantly reduced in the two groups after treatment(P＜0.05),and the levels of FPG and HbA1c in observation group were lower than those in control group(P＜0.05).Urinary al-bumin excretion rate(UAER),serum creatinine(Scr)and blood urea nitrogen(BUN)were significantly decreased in two groups after treatment(P＜0.05),and UAER,Scr and BUN were lower in observation group than those in control group(P＜0.05).After treatment,serum levels of interleukin-6(IL-6),tumor necrosis factor α(TNF-α)and C-reactive protein(CRP)in the two groups were significantly declined(P＜0.05),and serum levels in observation group were lower than those in control group(P＜0.05).Conclusion Dialectical addition and subtraction of Huashi Xiuzhuo decoction in the treatment of DKD of upper energizer dampness-heat syndrome is beneficial to reducing inflammatory response and improving glucose metabolism and renal function,and it has a positive effect on improving the efficacy.关键词
糖尿病肾病/上焦湿热证/化湿泻浊方/肾功能/炎症因子Key words
Diabetic kidney disease/Upper energizer dampness-heat syndrome/Huashi Xiuzhuo decoction/Renal func-tion/Inflammatory factors分类
医药卫生引用本文复制引用
赵慧芳,傅文,马梦圆,杜雨晨,杨巧菊,徐慧..化湿泻浊方辨证加减治疗糖尿病肾病(DKD)上焦湿热证的效果及对炎症反应的影响[J].四川中医,2023,41(10):136-140,5.基金项目
河南省健康委员会,河南省中医药科学研究专项课题(编号:2021ZY2026). （编号:2021ZY2026）
