陕西中医2024，Vol.45Issue(1)：132-135,4.DOI:10.3969/j.issn.1000-7369.2024.01.031
活血化瘀方药调控水通道蛋白研究概况
Research progress on regulation of Aquaporin by blood-activating and stasis-dissolving drugs
摘要
Abstract
Zhang Zhongjing put forward the theory of traditional Chinese medicine that Xuebuli Zeweishui,pointed out the pathological relationship between blood and water,that is,the pathogenesis of water caused by blood stasis,which provided ideas for later generations of doctors to treat water metabolism disorders by activating blood and resolving stasis,but its molecular biological mechanism is not clear.Aquaporins are important in maintaining the balance of water metabolism in the body.When AQPs are abnormal,the dynamic balance of human water is broken,which can cause many diseases.In recent years,a large number of studies have confirmed that Blood-Activating and Stasis-Dissolving drugs can treat brain edema,pulmonary edema,constipation,tissue swelling and other body fluid metabolic diseases by regulating the expression level of AQPs.Based on this,it is proposed to review the abnormal expression of AQPs in water metabolism disorders and the regulatory mechanism of Blood-Activating and Stasis-Dis-solving drugs,so as to provide a molecular biological theoretical basis for Xuebuli Zeweishui,in order to provide refer-ence for further research and clinical application.关键词
活血化瘀方药/水通道蛋白/水液代谢/血不利则为水/血水同病/血水同治Key words
Blood-activating and stasis-dissolving drugs/Aquaporins/Water metabolism/Xuebuli Zeweishui/Xueshui Tongbing/Xueshui Tongzhi分类
医药卫生引用本文复制引用
袁晨,姜华,邢文文,张睿轩,李锦虹,伽雨龙,王郁金..活血化瘀方药调控水通道蛋白研究概况[J].陕西中医,2024,45(1):132-135,4.基金项目
国家自然科学基金资助面上项目(81973865) （81973865）
陕西省科技发展计划项目(2022SF-226) （2022SF-226）
陕西省咸阳市科技计划项目(2021ZDYF-SF-0014) （2021ZDYF-SF-0014）
