生物医学工程研究2023，Vol.42Issue(4)：344-349,6.DOI:10.19529/j.cnki.1672-6278.2023.04.06
基于磁动光学相干弹性成像的组织力学特性评估
Evaluation of tissue mechanical properties based on magnetomotive optical coherence elastography
摘要
Abstract
The magnetomotive optical coherence elastography(MM-OCE)can detect the tiny vibrations of the tissue loaded with magnetic particles,analyze the vibration information,and extract the parameters that can reflect the biomechanical properties of the tis-sue.We used the solenoid magnetic excitation and optical coherence tomography acquisition to establish the MM-OCE research plat-form,which records the vibration response of the tissue loaded with magnetic nanoparticles under the excitation of the sweep signal to determine the mechanical resonance frequency of the tissue,so as to characterize the biomechanical properties of the tissue semi-quan-titatively.The results showed that the resonant frequency increased when the portion of gelatin was enhanced in the gelatin phantom,in-dicating the increase in stiffness for the gelatin phantoms.After cross-linking treatment with glutaraldehyde collagen on the ex vivo cor-nea,the resonance frequency of ex vivo corneas increased with the increase of glutaraldehyde concentration,indicating that the reso-nance frequency could reflect the difference of corneal hardness.This research can evaluate the difference of mechanical properties of tissues and has great potential for clinical application.关键词
生物医学测量学/弹性成像/光学相干层析成像/磁动成像/磁性纳米颗粒/生物力学Key words
Biomedical measurement/Elastography/Optical coherence tomography/Magnetomotive imaging/Magnetic nanoparti-cles/Biomechanics分类
医药卫生引用本文复制引用
肖婷,荣子琦,覃茜,张新宇..基于磁动光学相干弹性成像的组织力学特性评估[J].生物医学工程研究,2023,42(4):344-349,6.基金项目
深圳市基础研究项目(JCYJ20190808141605481). （JCYJ20190808141605481）
