生物医学工程研究2023，Vol.42Issue(4)：362-367,6.DOI:10.19529/j.cnki.1672-6278.2023.04.09
吸气-按压间隔时间对哮喘药物颗粒沉积影响的数值仿真分析
Numerical simulation analysis of the effect of inhalation-pressure interval on the asthma drug particle deposition
摘要
Abstract
In order to analyze the effect of inspiration-press interval on the deposition of drug particles in vivo,the numerical simu-lation was used to analyze the distribution of drug particles in vivo deposition in asthma patients when using metered-dose inhalers.Firstly,the 3D numerical model of human respiratory tract was reconstructed from CT data obtained in clinic.Then,the geometric mod-el of asthma metered-dose inhaler was established and combined with the previous respiratory model.Finally,the computational fluid dynamics method was used to simulate the in vivo transport of asthma drug particles.The results showed that with the Δt shortened,the deposition rate of drug particles in the oropharynx gradually decreased,while the deposition rate of particles in the lower airway gradual-ly increased.When Δt=0 s,the deposition fraction of particles in the oropharynx decreased to the lowest value of 49.87%,and the cor-responding particles entering the lower airway reached the highest value of 35.04%.It can provide important theoretical guidance for in-telligent assisted drug delivery technology in the future,so as to improve the efficiency of drug delivery.关键词
哮喘/定量吸入器/计算流体动力学/吸气-按压间隔时间/沉积率Key words
Asthma/Metered-dose inhaler/Computational fluid dynamics/Inspiration-press interval/Deposition rate分类
医药卫生引用本文复制引用
严思鑫,冯森,崔彪,张治国..吸气-按压间隔时间对哮喘药物颗粒沉积影响的数值仿真分析[J].生物医学工程研究,2023,42(4):362-367,6.基金项目
国家自然科学基金资助项目(32071319,11472062) （32071319,11472062）
中央高校基本科研业务费(2019B01314). （2019B01314）
