世界中医药2023，Vol.18Issue(21)：3109-3112,3117,5.DOI:10.3969/j.issn.1673-7202.2023.21.020
肠道菌群对慢性疲劳综合征中枢神经系统的调控机制
Mechanism of Intestinal Flora Regulating the Central Nervous System of Patients with Chronic Fatigue Syndrome
摘要
Abstract
Chronic fatigue syndrome(CFS)is a neuroimmune disease characterized by unexplained fatigue for a long time and ina-bility to recover energy after sleep.As a key factor regulating the central nervous system,intestinal flora participates in the occur-rence and development of CFS.To clarify the mechanism of intestinal flora in the pathogenesis of CFS,this paper analyzed the intes-tinal flora and its metabolites affecting CFS based on the microorganism-gut-brain axis,and discussed the internal mechanism of in-testinal flora imbalance in weakening endotoxin tolerance,destroying intestinal barrier,changing intestinal flora metabolism to regu-late the central nervous system of CFS.The paper facilitates the further research on intestinal microorganisms of CFS patients and provide a new clinical idea for the prevention and treatment of CFS.关键词
肠道菌群/慢性疲劳综合征/微生物-肠-脑轴/中枢神经系统/肠道屏障/内毒素耐受/神经炎症Key words
Intestinal flora/Chronic fatigue syndrome/Microorganism-gut-brain axis/Central nervous system/Intestinal barrier/Endotoxin tolerance/Neuritis分类
医药卫生引用本文复制引用
顾元嘉,谢芳芳,管翀,王桂茂,成子己,张帅攀,郭光昕,姚斐..肠道菌群对慢性疲劳综合征中枢神经系统的调控机制[J].世界中医药,2023,18(21):3109-3112,3117,5.基金项目
国家自然科学基金面上项目(81774443) （81774443）
