世界中医药2023，Vol.18Issue(21)：3143-3148,6.DOI:10.3969/j.issn.1673-7202.2023.21.025
白术对慢传输型便秘的药理作用及临床配伍应用研究现状
Research Status on Pharmacological Effects and Clinical Compatibility of Atractylodis Macrocephalae Rhizoma on Slow-transit Constipation
摘要
Abstract
Atractylodis Macrocephalae Rhizoma is one of the classical herbs used in the management of qi and spleen,which has the effect of harmonizing the spleen and stomach,strengthening the spleen and benefiting qi,drying dampness and inducing diure-sis,stopping sweating,and calming the fetus.Modern pharmacological studies have shown that Atractylodis Macrocephalae Rhizoma contains many effective active ingredients,such as volatile oils and lactones.It has anti-inflammatory,antibacterial,and neuroprotec-tive effects and can effectively improve intestinal flora and metabolites and regulate gastrointestinal hormones and neurotransmitters.The current incidence of slow-transit constipation(STC)is getting higher,and the severe cases are even life-threatening,affecting people's quality of life.Studies have shown that Atractylodis Macrocephalae Rhizoma has a good effect in treating STC and can ef-fectively improve the symptoms of patients with STC.Through literature review,the relevant pharmacological effects of Atractylodis Macrocephalae Rhizoma and its active ingredients in STC were summarized,and the mechanisms of Atractylodis Macrocephalae Rhizoma and its compounds and classical formulas to treat STC through Cajal interstitial cells(ICC),intestinal neurotransmitters,intestinal smooth muscle,and water channel proteins(AQPs)were analyzed,so as to provide corresponding references for clinical standardization of medication.关键词
白术/活性成分/慢传输型便秘/药理作用/肠道运动/神经递质/临床配伍/方剂Key words
Atractylodis Macrocephalae Rhizoma/Active ingredients/Slow-transit constipation/Pharmacological effects/Intesti-nal movement/Neurotransmitters/Clinical compatibility/Formulas分类
医药卫生引用本文复制引用
司香环,李东娜,李宏佳,徐天舒..白术对慢传输型便秘的药理作用及临床配伍应用研究现状[J].世界中医药,2023,18(21):3143-3148,6.基金项目
国家自然科学基金面上项目(82273907) （82273907）
南京市卫生科技发展专项资金项目(ZKX21020) （ZKX21020）
