陕西医学杂志2024，Vol.53Issue(1)：109-112,117,5.DOI:10.3969/j.issn.1000-7377.2024.01.024
单核细胞/高密度脂蛋白胆固醇比值、成纤维细胞生长因子21、C肽表达水平与2型糖尿病性骨质疏松症相关性分析
Correlation between the expression levels of MHR,FGF21,C peptide and type 2 diabetic osteoporosis
摘要
Abstract
Objective:To analyze the correlation between monocyte/high-density lipoprotein cholesterol ratio(MHR),fibroblast growth factor 21(FGF21),C-peptide expression levels and osteoporosis in patients with type 2 diabetes mellitus(T2DM).Methods:A total of 90 patients with T2DM osteoporosis were selected as the study group,and 57 patients with simple T2DM treated in the hospital during the same period were selected as the refer-ence group.The general data,osteocalcin(BGP),25-hydroxyvitamin D3[[25(OH)D3],N-terminal propeptide of typeⅠ procollagen(PINP),MHR,FGF21 and C-peptide levels were compared between the two groups.Spearman rank correlation was used to analyze the correlation between MHR,FGF21,C-peptide and BGP,25(OH)D3,PINP.Multi-variate Logistic regression analysis was used to analyze the risk factors of osteoporosis in T2DM patients.ROC curve was drawn to evaluate the diagnostic value of MHR,FGF21,C-peptide and their combined detection for osteoporosis in patients with T2DM.Results:The proportion of women in the study group was higher than that in the reference group(P＜0.05).The level of MHR in the study group was higher than that in the reference group,and the levels of BGP,25(OH)D3,PINP,FGF21 and C-peptide were lower than those in the reference group(all P＜0.05).Spearman correlation analysis showed that MHR was negatively correlated with BGP,25(OH)D3 and PINP,while FGF21 and C-peptide were positively correlated with BGP,25(OH)D3 and PINP(all P＜0.05).Multivariate Logistic regression analysis showed that MHR was a risk factor for osteoporosis in T2DM patients,and FGF21 and C-peptide were pro-tective factors for osteoporosis in T2DM patients(all P＜0.05).The results of ROC curve showed that the area un-der the curve of MHR,FGF21,C-peptide and their combined detection in predicting osteoporosis in T2DM patients was 0.894,0.759,0.810 and 0.969,respectively.Conclusion:The level of MHR in T2DM patients with osteoporosis increases,the levels of FGF21 and C-peptide decrease,and the above indicators are closely related to osteoporosis in T2DM patients.The combined detection of MHR,FGF21 and C-peptide levels has a good application value in predic-ting osteoporosis in T2DM patients.关键词
单核细胞/高密度脂蛋白胆固醇比值/成纤维细胞生长因子21/C肽/2型糖尿病/骨质疏松Key words
Monocyte/HDL-C ratio/Fibroblast growth factor 21/C peptide/Type 2 diabetes mellitus/Osteo-分类
医药卫生引用本文复制引用
刘强,何丽,李素芳,苟伟..单核细胞/高密度脂蛋白胆固醇比值、成纤维细胞生长因子21、C肽表达水平与2型糖尿病性骨质疏松症相关性分析[J].陕西医学杂志,2024,53(1):109-112,117,5.基金项目
四川省卫生健康委员会医学科技项目(21PJ154) （21PJ154）
