陕西医学杂志2024，Vol.53Issue(1)：113-117,5.DOI:10.3969/j.issn.1000-7377.2024.01.025
微小RNA-155和血清β2微球蛋白检测在血液透析患者并发心血管疾病中的诊断价值
Diagnostic value of microRNA-155 and serum β2-microglobulin in hemodialysis patients with cardiovascular disease
摘要
Abstract
Objective:To investigate the correlation between the expression of microRNA-155(miRNA-155),serum β2-microglobulin and the risk of cardiovascular disease in hemodialysis patients.Methods:A totalo of 100 he-modialysis patients which have cardiovascular diseases were chose as the experimental group.At the same time,100 hemodialysis patients without cardiovascular were selected as the control group.There were blood samples collection from the 200 selected hemodialysis patients,and the serum soluble growth stimulating gene 2 protein(sST2),tropo-nin T(TNT)and serum N-terminal pro-brain natriuretic peptide(NT-proBNP)were detected.All subjects were as-sessed for cardiovascular disease.The level of miRNA-155 in serum was examined by qPCR.The serum β2-micro-globulin level was detected by rate scattering turbidimetry.Results:The age,the proportion of diabetes history,the average age of starting dialysis,the average level of TNT,the mean level of NT-proBNP and sST2 in the experimen-tal group were higher than those in the control group(all P＜0.05).At the same time,the average dialysis time in the control group was longer than the average dialysis time in the experimental group(P＜0.05).The content of miRNA-155 in serum of experimental group was significantly lower than that of control group(P＜0.05).Mean-while,the expression level of serum miRNA-155 was negatively correlated with the levels of TNT,NT-proBNP and sST2(all P＜0.05).The content of β2-microglobulin in serum of experimental group was significantly higher than that of control group(P＜0.05).At the same time,the level of serum β2-microglobulin was positively correlated with the levels of TNT,NT-proBNP and sST2(all P＜0.05).ROC curve analysis showed that the AUC of serum miRNA-155 and β2-microglobulin were 0.912(95％CI:0.798 to 0.985)and 0.842(95％CI:0.793 to 0.972),re-spectively.Conclusion:The sST2,TNT and NT-proBNP can effectively diagnose cardiovascular diseases in hemodial-ysis patients,and the expression level of miRNA-155 in serum of hemodialysis patients with cardiovascular diseases is low,the expression level of serum β2-microglobulin is high.Therefore,miRNA-155 and serum β2-microglobulin have outstanding value in predicting cardiovascular diseases in hemodialysis patients.关键词
微小RNA-155/血清β2微球蛋白/心血管疾病/血液透析/可溶性生长刺激表达基因2蛋白/肌钙蛋白T/氨基末端脑利钠肽前体Key words
miRNA-155/Serumβ2-microglobulin/Cardiovascular disease/Haemodialysis/sST2/TNT/NT-proBNP分类
医药卫生引用本文复制引用
杨亚琴,杨文,刘淑婷,孙亦兵..微小RNA-155和血清β2微球蛋白检测在血液透析患者并发心血管疾病中的诊断价值[J].陕西医学杂志,2024,53(1):113-117,5.基金项目
河北省卫生健康委员会科研计划项目(20231423) （20231423）
