陕西医学杂志2024，Vol.53Issue(1)：118-121,4.DOI:10.3969/j.issn.1000-7377.2024.01.026
血清S-100B蛋白、可溶性凝集素样氧化低密度脂蛋白受体-1、胶质纤维酸性蛋白检测在新生儿缺血缺氧性脑病病情严重程度中的诊断价值
Diagnostic value of serum S-100B protein,sLOX-1 and GFAP in severity of neonatal hypoxic-ischemic encephalopathy
摘要
Abstract
Objective:To investigate the relationship between serum S-100B protein,soluble lectin like oxidized low density lipoprotein receptor-1(sLOX-1),glial fibrillary acidic protein(GFAP)and the severity of neonatal hy-poxic encephalopathy(HIE).Methods:Eighty children with HIE were selected as the observation group,and 90 healthy newborns were selected as the control group.General data of all children were collected,and serum S-100B protein,sLOX-1 and GFAP levels were detected in the two groups.The correlation of serum S-100B protein,sLOX-1,GFAP with the severity of HIE and the influencing factors of poor prognosis were analyzed.Results:the control group of serum S-100B protein,sLOX-1,GFAP level is lower than the observation group(all P＜0.05).Serum levels of S-100B protein,sLOX-1 and GFAP in severe group were higher than those in moderate group,mild group and control group(all P＜0.05).Pearson correlation analysis showed that the disease severity was positively correlated with the levels of S-100B protein,sLOX-1 and GFAP in serum of HIE children(all P＜0.05).A total of 59 children with good prognosis and 21 with poor prognosis were followed up.Multivariate Logistic regression analysis showed that abnormal labor process,severity of disease,S-100B protein,sLOX-1 and GFAP were the risk factors affecting the prognosis of HIE children(all P＜0.05).Conclusion:The severity and prognosis of HIE children are related to the levels of serum S-100B protein,sLOX-1 and GFAP,and monitoring the changes of their levels is conducive to impro-ving the early clinical intervention plan and improving the prognosis.关键词
S-100B蛋白/可溶性凝集素样氧化低密度脂蛋白受体-1/胶质纤维酸性蛋白/新生儿缺血缺氧性脑病/相关性/预后Key words
S-100B protein/Soluble lectin-like oxidized low density lipoprotein receptor-1/Glial fibrillary acidic protein/Neonatal hypoxic-ischemic encephalopathy/Correlation/Prognosis分类
医药卫生引用本文复制引用
耿淑霞..血清S-100B蛋白、可溶性凝集素样氧化低密度脂蛋白受体-1、胶质纤维酸性蛋白检测在新生儿缺血缺氧性脑病病情严重程度中的诊断价值[J].陕西医学杂志,2024,53(1):118-121,4.基金项目
国家自然科学基金资助项目(82173519) （82173519）
河北省邢台市科技计划项目(2023ZC) （2023ZC）
