陕西医学杂志2024，Vol.53Issue(1)：132-135,4.DOI:10.3969/j.issn.1000-7377.2024.01.029
铁死亡在脑缺血再灌注中的作用研究进展
Research progress on ferroptosis in cerebral ischemia-reperfusion injuries
摘要
Abstract
Ferroptosis is an iron-dependent,regulated form of cell death caused by lipid peroxidation and mas-sive accumulation of reactive oxygen species.Numbers of studies showed that ferroptosis is intimately related to the progression and prognosis of cerebral ischemia-reperfusion injuries(CIRI).For now,the targets of ferroptosis in CIRI are still iron metabolism and consumption of lipid peroxides.At present,there have been massive studies on the regu-latory mechanism of ferroptosis,such as System Xc-/GPX4,FSP1/CoQ10,DHODH/CoQ10,and GCH1/BH4,from which we can also find out lots of targets for clinical treatment.This article is going to provide some new targets and ideas for subsequent researches through reviewing the key components of ferroptosis,pathways and the applications in mitigating CIRI damage.关键词
铁死亡/缺血性脑卒中/细胞通路/铁代谢/脂质过氧化Key words
Ferroptosis/Cerebral ischemia-reperfusion injury/Cell pathway/Iron metabolism/Lipid peroxidation分类
医药卫生引用本文复制引用
施嘉华,陈真珍,黄龙坚,王凯华..铁死亡在脑缺血再灌注中的作用研究进展[J].陕西医学杂志,2024,53(1):132-135,4.基金项目
国家自然科学基金资助项目(82360870) （82360870）
广西中医药大学校级科研项目(2021MS011) （2021MS011）
广西壮族自治区中医药管理局自筹经费科研课题(GXZYZ20210103) （GXZYZ20210103）
广西中医药大学第二批"岐黄工程"高层次人才团队培育项目(2021008) （2021008）
广西壮族自治区南宁市良庆区科技基地专项课题(202211) （202211）
广西壮医火路病临床研究中心广西中医脑病重点学科建设项目(GZXK-Z-20-14) （GZXK-Z-20-14）
