实验动物与比较医学2023，Vol.43Issue(6)：654-658,5.DOI:10.12300/j.issn.1674-5817.2023.064
一例Han-Wistar大鼠垂体细胞瘤的病理学分析
Pathologic Diagnosis of a Pituicytoma in a Han-Wistar Rat
摘要
Abstract
A case of pituicytoma was observed in a Han-Wistar rat from the control group of a 2-year carcinogenicity study.No obvious abnormality were found in clinical observation and necropsy.Hematoxylin and Eosin(HE)staining results showed that nodular hyperplasia in the pars nervosa of the pituitary,which was well demarcated and compressed the adjacent normal tissue.The tumor cells were similar to the glial cells with round or oval nuclei,cytoplasm rich in eosinophilic or vacuole.The tumor cells differentiated well,with no obvious cell pleomorphism and visible mitotic figures.Some tumor cells were arranged in a pseudorosette formation.Immunohistochemical staining(IHC)analysis confirmed positive expression of Glial fibrillary acidic protein(GFAP)and S-100 protein.The tumor was diagnosed as the spontaneous benign pituicytoma combining the HE and IHC staining results.关键词
垂体细胞瘤/Han-Wistar大鼠/病理学诊断Key words
Pituicytoma/Han-Wistar rat/Pathological diagnosis分类
医药卫生引用本文复制引用
侯敏博,崔甜甜,苏娜瑛,张苗苗,焦永敏,严建燕,汪溪洁,大平东子..一例Han-Wistar大鼠垂体细胞瘤的病理学分析[J].实验动物与比较医学,2023,43(6):654-658,5.基金项目
上海市科委研发平台项目"新药安全评价专业技术服务平台"(21DZ2291000) （21DZ2291000）
