实用肝脏病杂志2024，Vol.27Issue(1)：56-59,4.DOI:10.3969/j.issn.1672-5069.2024.01.015
苦黄注射液预防抗结核药物导致的药物性肝损伤患者疗效研究
Administration of Kuhuang,a herbal injection compound,in preventing anti-tuberculosis drug-induced liver injury in patients with naïve pulmonary tuberculosis
摘要
Abstract
Objective This study was to observe the Kuhuang,a herbal injection compound,in preventing anti-tuberculosis drugs(ATD)-induced liver injury(DILI)for avoiding unreasonable anti-tuberculosis treatment interruption.Methods A total of 97 patients with naïve pulmonary tuberculosis were encountered in our hospital between March 2022 and November 2022,and were randomly divided into control(n=47)and observation(n=50)groups,receiving standardized 2HREZ/4HR anti-tuberculosis therapy,or intravenous injection of Kuhuang compound at base of anti-tuberculosis for 8 weeks.Serum interleukin-6(IL-6)and tumor necrosis factor-α(TNF-α)levels were detected by ELISA,and serum heme oxygenase(HO-1)and superoxide dismutase(SOD)levels were detected by radioimmunoassay.Results At the end of 4 week anti-tuberculosis treatment,the incidences of adaptive liver injury(ALI)and DILI in the observation group were 6.0%and 2.0%,much lower than 17.0%and 8.5%(P<0.05)in the control,and at the end of 8 week treatment,the incidences of ALI and DILI were 6.0%and 4.0%,much lower than 21.3%and 17.0%(P<0.05)in the control group;at the end of 8 week treatment,serum ALT,AST and total bilirubin levels in the observation group were(28.4±23.4)U/L,(30.8±18.7)U/L and(12.9±7.3)μmol/L,all significantly lower than[(53.1±33.1)U/L,(52.5±37.7)U/L and(20.1±10.9)μmol/L,respectively,P<0.05]in the control;serum HO-1 and SOD levels were(200.3±14.0)U/L and(418.0±18.7)U/L,both significantly higher than[(128.8±21.4)U/L and(318.0±15.1)U/L,P<0.05],while serum IL-6 and TNF-α levels were(11.4±1.9)ng/L and(9.3±1.8)ng/L,both significantly lower than[(17.5±4.0)ng/L and(14.5±3.0)ng/L,respectively,P<0.05]in the control.Conclusion The administration of Kuhuang injection compound could prevent the occurrence of anti-tuberculosis DILI,and guarantee the standardized anti-tuberculosis treatment completing.关键词
药物性肝损伤/肺结核/抗结核药物/适应现象/苦黄/预防Key words
Drug-induced liver injury/Pulmonary tuberculosis/Antituberculosis medicines/Adaptation phenomenon/Kuhuang injection,herbal medicine/Prevention引用本文复制引用
任浩,刘力伟,施维,刘波,吴于青,吕芹..苦黄注射液预防抗结核药物导致的药物性肝损伤患者疗效研究[J].实用肝脏病杂志,2024,27(1):56-59,4.基金项目
安徽省教育厅重点自然科学研究基金结核分枝杆菌分子生物学检测技术及耐药性研究项目(编号:KJ2020A0863) （编号:KJ2020A0863）
