山西医科大学学报2023，Vol.54Issue(11)：1477-1482,6.DOI:10.13753/j.issn.1007-6611.2023.11.007
平均红细胞体积与腹主动脉钙化评分及严重程度的关系
Correlation between mean corpuscular volume and abdominal aortic calcification score and severity
摘要
Abstract
Objective To investigate the relationship between the mean corpuscular volume(MCV)and the abdominal aortic calcifica-tion(AAC)score and the severity of AAC.Methods The abdominal aortic calcification population and the related laboratory data were collected from the National Health and Nutrition Examination Survey database by data collectors who used dual-energy X-ray absorptiometry to scan participants'lumbar vertebra.A total of 3 056 participants were included in the study and the degree of abdominal aortic calcification was measured using the Kauppila score system.Kauppila=0,0＜Kauppila＜6,and Kauppila ≥6 were defined as no abdominal aortic calcification,mild to moderate abdominal aortic calcification,and severe abdominal aortic calcification,respectively.Participants were divided into Q1 group,Q2 group,Q3 group and Q4 group according to the MCV quartile.Weighted person correla-tion analysis,linear regression analysis and multinomial Logistic regression were used to analyze the relationships between MCV and AAC score and AAC severity.Results Participants were divided into four groups based on the MCV quartile,there were 762 cases in Q1 group,765 cases in Q2 group,759 cases in Q3 group,and 770 cases in Q4 group.AAC score,and the proportions of patients with mild-moderate AAC and severe AAC gradually increased from Q1 group to Q4 group(P＜0.05).Person correlation analysis showed that MCV was positively correlated with AAC score(r=0.083,P＜0.001).Linear regression analysis showed that AAC score increased by 0.048 for each 1 fl increase of MCV(95％CI 0.028-0.069,P＜0.001).Multinomial Logistic regression analysis showed that after adjusting for multiple risk factors such as sex and age,the probability of mild-moderate AAC increased by 0.47％for every 1 fl increase of MCV(OR=1.004 7,95％CI 1.004 6-1.004 7,P＜0.001)and the likelihood of severe AAC increased by 3.06％(OR=1.030 6,95％CI 1.030 5-1.030 7,P＜0.001).Conclusion MCV level is positively correlated with AAC score,and it is an independent risk factor for severe AAC.关键词
腹主动脉钙化/平均红细胞体积/心血管疾病/NHANES数据库/危险因素Key words
abdominal aortic calcification/mean corpuscular volume/cardiovascular diseases/NHANES database/risk factors分类
医药卫生引用本文复制引用
孟子喧,白晓芳,郝翔,荐志洁,吴岳,成乐乐..平均红细胞体积与腹主动脉钙化评分及严重程度的关系[J].山西医科大学学报,2023,54(11):1477-1482,6.基金项目
国家自然科学基金资助项目(82200500) （82200500）
国家重点研发计划项目(2019YFA0802300) （2019YFA0802300）
