实用医学杂志2023，Vol.39Issue(23)：3116-3119,4.DOI:10.3969/j.issn.1006-5725.2023.23.016
前瞻性队列研究—甘油三酯葡萄糖指数与急性胰腺炎发病风险
Correlation between triglyceride glucose index and risk of acute pancreatitis:A prospective cohort study
摘要
Abstract
Objective To investigate the correlations of triglyceride glucose index(TyG)levels at different baselines with the risk of new-onset acute pancreatitis(AP)among the workers at Kailuan Group.Methods A total of 124 516 subjects were enrolled from 2006 to 2009 and followed up by health examinations of the workers in the group.The subjects with a history of AP or incomplete information on TG and FPG data were excluded.The cumulative incidence rate was determined by Log-Rank method.Multivariate Cox proportional hazards regression model was used to calculate hazard ratios(HR)for AP related to baseline TyG level after adjusting for the effects of multiple confunding factors.Results The subjects were divided into four groups(TyG≤6.59,6.59<TyG≤6.98,6.98<TyG4≤7.46,TyG>7.46)according to the TyG levels,and the incidence of new-onset AP was observed in all the groups.For a follow-up of(12.59±0.98)years,399 cases of AP were observed.The corresponding incidence of AP in each tertile was 1.67,2.32,2.53,and 3.65 events per 10,000 person-years,respectively.After Cox analysis and correction of multiple confounding factors,the risk of AP incidence was increased in the TyG>7.46 group,with an HR of 1.94[(95%CI(1.42,2.65),P<0.01].Conclusion TyG at its baseline of above 7.46 can increase the risk of AP.关键词
甘油三酯葡萄糖指数/急性胰腺炎/代谢综合征/胰岛素抵抗Key words
triglyceride glucose index/acute pancreatitis/metabolic syndrome/insulin resistance分类
医药卫生引用本文复制引用
张冰,孙秋,杜丽明,陈朔华..前瞻性队列研究—甘油三酯葡萄糖指数与急性胰腺炎发病风险[J].实用医学杂志,2023,39(23):3116-3119,4.基金项目
河北省卫健委科研立项(编号:20221167) （编号:20221167）
