实用医学杂志2023，Vol.39Issue(23)：3143-3148,6.DOI:10.3969/j.issn.1006-5725.2023.23.021
A1型星形胶质细胞:治疗神经退行性和神经炎性疾病的新靶点
A1 astrocytes:A new target for the treatment of neurodegenerative and neuroinflammatory diseases
摘要
Abstract
Astrocytes constitute the most abundant cell type in the central nervous system.Under physi-ological conditions,astrocytes have a variety of functions,and play an important role in maintaining the homeostasis of the central nervous system.However,in response to insults such as injury,inflammation and hypoxia,astro-cytes undergo rapid changes in gene expression,morphology and function,and these responses collectively called as astrocyte reactivity.Activated astrocytes have been divided into neurotoxic phenotype(type A1)and neuropro-tective phenotype(type A2).Recent studies have shown that A1 astrocytes are widely involved in the occurrence and development of various central nervous system diseases.Therefore,targeted regulation of activated astrocytes by combining multiple techniques is expected to be a potential treatment for central nervous system diseases.Here,we review recent advances of A1 astrocytes,including the molecular mechanism of phenotypic transformation and its role in neurodegenerative and neuroinflammatory diseases.关键词
A1型星形胶质细胞/中枢神经系统/神经退行性疾病/神经炎性疾病/治疗靶点Key words
A1 astrocyte/central nervous system/neurodegenerative diseases/neuroinflammatory diseases/therapeutic target分类
医药卫生引用本文复制引用
许威,彭涛,曾梦柳..A1型星形胶质细胞:治疗神经退行性和神经炎性疾病的新靶点[J].实用医学杂志,2023,39(23):3143-3148,6.基金项目
湖北省卫健委面上项目(编号:WJ2023M036) （编号:WJ2023M036）
