实用妇产科杂志2023，Vol.39Issue(12)：934-938,5.
激动剂方案和拮抗剂方案对波塞冬组1人群的疗效分析
Efficacy Analysis of Gonadotropin-Releasing Hormone Agonist Protocol and Gonadotropin-Releasing Hormone Antagonist Protocol in POSEIDON Group 1
摘要
Abstract
Objective:To evaluate the effect of gonadotropin-releasing hormone agonist(GnRH-a)protocol and gonadotropin-releasing hormone antagonist(GnRH-ant)protocol in POSEIDON group 1.Methods:From January 2019 to December 2020,399 patients in POSEIDON group 1 who underwent assisted reproductive technology in the Center of Reproductive Medicine,Affiliated Hospital of Nantong University were retrospectively analyzed.Cohorts with similar baseline characteristics were screened by 1 ∶1 propensity score matching(PSM),and base-line data,clinical and laboratory parameters,and clinical outcomes were compared between GnRH-a and Gn-RH-ant groups.Results:①100 patients from GnRH-a group and 100 patients from GnRH-ant group were matched.②The total dose and total use time of gonadotropin(Gn)in GnRH-a group were higher than those in GnRH-ant group(P<0.001,P =0.048),and the hormone levels of luteinizing hormone,estradiol and progester-one on the day of HCG injection were lower than those in GnRH-ant group(P<0.001,P =0.011,P<0.001).There was no statistical difference in the number of follicles between the two groups(P>0.05),the number of oocytes retrieved,mature oocytes,normal fertilized oocytes,high-quality embryos and available embryos were lower in GnRH-a group than those in GnRH-ant group(P<0.01).③In GnRH-a group,the time to live birth(TTLB)was higher than GnRH-ant group(P =0.005),and the cumulative live birth rate(CLBR)was lower than GnRH-ant group(P =0.048),and there was no statistical difference in the number of transplants(P =0.536)and cumulative pregnancy rates(P =0.084)between the two groups.④The economic cost to live birth of GnRH-a group was higher than that of GnRH-ant group(P =0.02).Conclusions:Compared with GnRH-a group,Gn-RH-ant group could improve the cumulative live birth rate of a single ovulation induction cycle in patients in PO-SEIDON group 1,shorten the time to live birth and reduce the treatment cost of patients,and was the preferred protocol for patients in POSEIDON group 1.关键词
累积活产率/累积妊娠率/促性腺激素释放激素激动剂/促性腺激素释放激素拮抗剂/波塞冬标准Key words
Cumulative live birth rate/Cumulative pregnancy rate/GnRH agonist/GnRH antagonist/POSEI-DON criteria分类
医药卫生引用本文复制引用
顾小铃,陈艳男,王青欣,王迪,王霞..激动剂方案和拮抗剂方案对波塞冬组1人群的疗效分析[J].实用妇产科杂志,2023,39(12):934-938,5.基金项目
江苏省卫生健康委科研项目合同书(编号:Z2022069) （编号:Z2022069）
南通市基础研究和民生科技计划(编号:JCZ21008、MSZ2022051) （编号:JCZ21008、MSZ2022051）
南通大学附属医院多中心临床研究项目(编号:LCYJ-B05) （编号:LCYJ-B05）
