实用妇产科杂志2023，Vol.39Issue(12)：939-943,5.
拮抗剂方案黄体支持中添加GnRH-a对新鲜周期临床结局的影响
Effect of Adding GnRH-a in Luteal Support of Fresh Embryo Transfer Cycles with GnRH Antagonist Protocol on Clinical Outcomes
摘要
Abstract
Objective:To compare the effect of luteal-phase support administration of gonadotrophin-releasing hormone agonist(GnRH-a)on the outcomes of fresh embryo transfer in GnRH antagonist cycles,and explore a more appropriate protocol of luteal-phase support.Methods:A retrospective analysis was performed on the infer-tility patients who receiving in vitro fertilization or intracytoplasmic sperm injection embryo transfer(IVF/ICSI-ET)in the Reproductive Medicine Center of our hospital from January 2018 to December 2021.Our study collected clini-cal data from 674 cycles of infertility patients undergoing fresh cycle transplantation using antagonist regimens.The patients were divided into the control group(n =348)and the observation group(n =326)according to if Gn-RH-a was added to the luteal phase.The patients in control group were given standard luteal support treatment,while the patients in observation group were given multiple-dose GnRH-a 0.1mg to standard luteal support treat-ment after egg retrieval.The general data,ovulation induction and clinical outcome were compared between the two groups.Results:Between the two groups of patients,there was no statistically significant difference in age,years of infertility,body mass index(BMI),basal follicle stimulating hormone(bFSH),days and total amount of gonadotropin(Gn),chorionic gonadotropin(HCG),luteinizing hormone(LH),estradiol(E2)and progesterone(P),the number of retrieved oocytes,MII oocytes,number of embryos,normal fertilization rate,moderate to se-vere ovarian hyperstimulation syndrome(OHSS)rate,abortion rate,live birth rate,multiple pregnancy rate,inci-dence of pregnancy complications,birth weight of offspring,preterm birth rate,and birth defect rate(P>0.05).The implantation rate and clinical pregnancy rate were significantly higher in the observation group compared with control group(P<0.05).Multivariate Logistic regression analysis indicated that age and number of transferred embryos could influence the clinical pregnancy rate(OR 0.958,95%CI 0.917-1.000;OR 1.857,95%CI 1.173-2.942).Conclusions:In fresh embryo transfer cycles with GnRH antagonist protocol,on the basis of conventional luteal support,multi-dose intermittent short-acting GnRH-a for luteal support can achieve a good clin-ical outcome,and may be a suitable luteal support scheme for GnRH antagonist protocol in fresh embryo transfer cycles.关键词
体外受精-胚胎移植/促性腺激素释放激素激动剂/黄体支持/临床结局Key words
Invitro fertilization-embryo implantation/Gonadotropin-releasing hormone agonist/Luteal support/Clinical outcome分类
医药卫生引用本文复制引用
罗希,赵淑云,周桦,黄永俐,陈卓..拮抗剂方案黄体支持中添加GnRH-a对新鲜周期临床结局的影响[J].实用妇产科杂志,2023,39(12):939-943,5.基金项目
贵州省科技厅基础研究项目(编号:[2020]1Y337) （编号:[2020]1Y337）
