实用医学杂志2023，Vol.39Issue(24)：3200-3204,5.DOI:10.3969/j.issn.1006-5725.2023.24.009
急性大脑中动脉闭塞患者非高密度脂蛋白胆固醇水平变化及其与软脑膜侧支循环的关系
Relationship between non-high density lipoprotein cholesterol and leptomeningeal collaterals in patients with acute middle cerebral artery occlusion
摘要
Abstract
Objective To explore the relationship between non-high density lipoprotein cholesterol(non-HDL-C)level and leptomeningeal collateral circulation in patients with acute middle cerebral artery occlusion.Methods A total of 85 patients with first-onset acute cerebral infarction with middle cerebral artery M1 segment occlusion were enrolled.According to the results of DSA,LMC circulation was assessed by American Society of Interventional and Therapeutic Neuroradiology/Society of Interventional Radiology Collateral Circulation Assess-ment System.All patients were assigned to better LMC circulation group(score 2～4,n = 30)and worse LMC circulation group(score 0～1,n = 55),and the levels of non-HDL-C were compared between the two groups.Results The levels of LDL-C and non-HDL-C in worse LMC circulation group were significantly higher than those of the better LMC circulation group(P = 0.026,P = 0.010).non-HDL-C was an independent risk factor for the worse LMC circulation(OR = 3.019,95%CI:1.053～8.658,P = 0.04).LMC circulatory score of patients was negatively correlated with the levels of non-HDL-C level(r =-0.228,P = 0.036).The AUC of non-HDL-C predicted for the worse LMC circulation was 0.638(95%CI:0.521～0.755,P = 0.036).Conclusions non-HDL-C in patients with acute cerebral infarction was significantly related to worse LMC circulation,and was a risk factor for worse LMC circulation.It is suggested that the higher expression of non-HDL-C could be used to predict worse LMC circulation as a serological indicator.关键词
急性大脑中动脉闭塞/脑血管造影/非高密度脂蛋白胆固醇/软脑膜侧支循环Key words
acute middle cerebral artery occlusion/digital subtraction angiography/non-high density lipoprotein cholesterol/leptomeningeal collateral circulation分类
医药卫生引用本文复制引用
安怡,周莹杰,李雪斌,黄建敏,云艳芳,杨桂新,陈海燕,蒋勇明,黄东旭,莫晓榕,李晓岚,韦宝莹..急性大脑中动脉闭塞患者非高密度脂蛋白胆固醇水平变化及其与软脑膜侧支循环的关系[J].实用医学杂志,2023,39(24):3200-3204,5.基金项目
国家自然科学基金项目(编号:81860226) （编号:81860226）
