天津中医药2024，Vol.41Issue(1)：29-33,5.DOI:10.11656/j.issn.1672-1519.2024.01.07
半夏泻心汤加味联合四联疗法对脾胃湿热型Hp相关慢性胃炎患者Hp清除率及胃肠黏膜功能的影响
Effect of Banxia Xiexin Decoction combined with quadruple therapy on Hp clearance and gastrointestinal mucosal function in patients with damp-heat Hp-related chronic gastritis of the spleen and stomach
摘要
Abstract
[Objective]To explore the effect of Banxia Xiexin Decoction combined with quadruple therapy on the Hp clearance and gastric mucosa function in patients with Helicobacter pylori(Hp).[Methods]Collected in March 2020 to March 2022,92 cases of spleen and stomach dampness Hp related chronic gastritis,and the patients were divided into control group 45 cases,47 cases.The control group patients were treated with quadruple therapy,while the study group patients were treated with modified Banxia Xiexin Decoction on the basis of the control group.The changes in Hp clearance rate,gastrointestinal mucosal function,traditional Chinese medicine syndrome score,gastrointestinal hormones,and clinical efficacy of the two groups of patients were compared.[Results]After treatment,the expression levels of primary disease,secondary disease integral,Malondialdehyde(MDA)and vasoactine intrestinal peptide(VIP)were reduced,Gastrin-17(GAS-17),serum pepsinogen I(PGI),prostaglandin E2(PGE2),pepin,leptin expression levels,and the study group has improved compared with the control group(P＜0.05).The Hp clearance rate and total clinical effective rate of the study group were higher than those of the control group(P＜0.05).The total clinical response rate in the study group was higher than that in the control group(P＜0.05).[Conclusion]Banxia Xiexin Decoction combined with quadruple therapy has significant effect on the treatment of patients with spleen-stomach damp-heat type HP-related chronic gastritis,which can effectively reduce the symptoms of traditional Chinese medicine,increase the clearance rate of Hp,regulate the intestinal flora in the body,and improve the function of gastrointestinal mucosa,which is worthy of clinical application.关键词
半夏泻心汤/四联疗法/脾胃湿热型/幽门螺杆菌/慢性胃炎Key words
Banxia Xiexin Decoction/quadruple therapy/spleen and stomach dampness and heat type/Helicobacter pylori/chronic gastritis分类
医药卫生引用本文复制引用
刘婉,汪湃,晋颖,冯晓洁,王媛媛,刘宏伟..半夏泻心汤加味联合四联疗法对脾胃湿热型Hp相关慢性胃炎患者Hp清除率及胃肠黏膜功能的影响[J].天津中医药,2024,41(1):29-33,5.基金项目
北京市和平里医院科研项目(2020-2-04). （2020-2-04）
