无机材料学报2023，Vol.38Issue(12)：1441-1448,8.DOI:10.15541/jim20230198
电泳沉积制备微弧氧化钛表面氧化镁涂层及其生物学性能
Electrophoretic Coating of Magnesium Oxide on Microarc-oxidized Titanium and Its Biological Properties
摘要
Abstract
Titanium orthopaedic implants present a risk of infection and require the development of antibacterial,but still biocompatible and non-resistant coatings.Magnesium oxide(MgO)coatings were prepared on micro-arc oxidized titanium by electrophoretic deposition for 15,30,45,or 60 s.Nano-sized MgO particles agglomerated to form homogeneous coatings with surface coverage increasing with the duration of deposition.The four groups produced antibacterial rates of 1%,69%,83%,and 84%after co-cultured with S.aureus for 6 h,and 81%,86%,89%,and 98%after co-cultured for 24 h.Electron and fluorescence microscopies showed decreasing density of bacterial cells and proportion of living cells with increasing time of deposition.Mouse osteoblasts seeded on the four groups had survival rates of 108%,89%,53%,and 27%on day 1,and 139%,117%,112%,and 66%on day 5.Proportion of dead cells on the coated samples increased with increasing time of deposition but less than 5%on day 5.These results indicate that MgO coatings prepared by electrophoretic deposition for 30 s is reasonable in vitro antibacterial activities and cytocompatibility.关键词
钛/内置物/抗菌/微弧氧化/氧化镁/电泳沉积Key words
titanium/implant/antibacterial/micro-arc oxidation/magnesium oxide/electrophoretic deposition分类
医药卫生引用本文复制引用
杜佳恒,范鑫丽,肖东琴,尹一然,李忠,贺葵,段可..电泳沉积制备微弧氧化钛表面氧化镁涂层及其生物学性能[J].无机材料学报,2023,38(12):1441-1448,8.基金项目
国家自然科学基金面上项目(52071277) （52071277）
四川省科技计划(2020YFS0455,2022YFS0628) （2020YFS0455,2022YFS0628）
泸州市-西南医科大学合作项目(2020LZXNYDZ08,2020LZXNYDF02) （2020LZXNYDZ08,2020LZXNYDF02）
西南医科大学产学研项目(2022CXY03) （2022CXY03）
泸县西南医科大学联合课题(2020LXXNYKD-01)National Natural Science Foundation of China(52071277) （2020LXXNYKD-01）
Science&Technology Program of Sichuan Province(2022YFS0628,2020YFS0455) （2022YFS0628,2020YFS0455）
Luzhou-SWMU Cooperation Program(2020LZXNYDZ08,2020LZXNYDF02) （2020LZXNYDZ08,2020LZXNYDF02）
Industry-University Research Project of SWMU(2022CXY03) （2022CXY03）
Luxian-SWMU Joint Project(2020LXXNYKD-01) （2020LXXNYKD-01）
