陕西医学杂志2024，Vol.53Issue(1)：42-45,4.DOI:10.3969/j.issn.1000-7377.2024.01.009
彩色多普勒超声检查联合血清妊娠相关血浆蛋白-A、抑制素A、可溶性人类白细胞抗原G检测在先兆流产诊断和预后评估中的价值
Value of color Doppler ultrasound combined with serum pregnancy-associated plasma protein-A,Inhibin-A and soluble human leukocyte antigen G in diagnosis and prognosis of threatened abortion
摘要
Abstract
Objective:To investigate the value of color Doppler ultrasound combined with serum pregnancy-asso-ciated plasma protein-A(PAPP-A),Inhibin-A(INHA)and soluble human leukocyte antigen G(sHLAG)in the di-agnosis and prognosis of threatened abortion.Methods:A total of 108 patients with threatened abortion were selected as the study subjects,According to the pregnancy outcome after treatment,the patients were divided into continuing pregnancy group(65 cases)and abortion group(43 cases),and 60 healthy pregnant women with normal labor exami-nation during the same period were selected as the control group.The levels of PAPP-A,sHLAG and INHA,the val-ues of uterine artery blood flow Pulse Index(PI)and Resistance Index(RI),and the ratio of maximum systolic flow rate to minimum diastolic flow rate(S/D)were compared among the three groups.The predictive value of PAPP-A,sHLAG,INH A and PI,RI and S/D alone and combined in the diagnosis and prognosis of threatened abortion was an-alyzed by receiver operating characteristic(ROC)curve.Results:A total of 108 patients with threatened abortion were treated with tocolysis for 10 days,43 cases failed and 65 cases succeeded.The values of uterine artery blood flow PI,RI and S/D in the control group were lower than those in the continuing pregnancy group and the abortion group,the values of uterine artery blood flow PI,RI and S/D in the abortion group were higher than those in the continuing pregnancy group.The levels of serum PAPP-A and sHLAG in the continuing pregnancy group and the abortion group were lower than those in the control group,and the level of INHA was higher than that in the control group.The levels of serum PAPP-A and sHLAG in the abortion group were lower than those in the continuing pregnancy group,and the level of INHA was higher than that in the continuing pregnancy group(all P＜0.05).ROC curve a-nalysis showed that the area under the curve of the combined detection of serum PAPP-A,sHLAG,INHA and uter-ine artery blood flow PI,RI,S/D in the diagnosis and prognosis evaluation of threatened abortion was higher than that of each index alone(all P＜0.05).Conclusion:Color Doppler ultrasound combined with serum PAPP-A,sHLAG and INHA can be used in the diagnosis and prognosis assessment of threatened abortion,and the test has high energy efficiency.关键词
先兆流产/彩色多普勒超声/妊娠相关血浆蛋白A/抑制素A/可溶性人类白细胞抗原G/妊娠结局Key words
Threatened abortion/Color doppler ultrasound/Pregnancy-associated plasma protein-A/Inhibin-A/Soluble human leukocyte antigen G/Pregnancy outcome分类
医药卫生引用本文复制引用
陈寅,孙惟靖,张强..彩色多普勒超声检查联合血清妊娠相关血浆蛋白-A、抑制素A、可溶性人类白细胞抗原G检测在先兆流产诊断和预后评估中的价值[J].陕西医学杂志,2024,53(1):42-45,4.基金项目
国家自然科学基金资助项目(82173519) （82173519）
江苏省自然科学基金资助面上项目(BK20181235) （BK20181235）
