陕西医学杂志2024，Vol.53Issue(1)：55-58,63,5.DOI:10.3969/j.issn.1000-7377.2024.01.012
慢性肾衰竭患者并发心血管疾病相关危险因素分析
Related risk factors affecting cardiovascular diseases in patients with chronic renal failure
摘要
Abstract
Objective:To analyze the related risk factors of cardiovascular diseases(CVD)in patients with chro-nic renal failure(CRF).Methods:A total of 111 patients with CRF undergoing maintenance hemodialysiswere select-ed as research subjects.The incidence of CVD was investigated,and the patients were divided into CVD group(n=54)and non-CVD group(n=57).General clinical data of the two groups were collected,and Logistic univariate and multivariate regression analyses were performed to explore the independent risk factors of CVD in patients with CRF.Results:There were no statistically significant differences in age,gender,Body Mass Index(BMI),diabetes mel-litus,cardiovascular disease history and primary disease between the two groups(all P＞0.05).The levels of hemo-globin and Klotho protein in CVD group were lower than those in non-CVD group(all P＜0.05),while the levels of low density lipoprotein cholesterol(LDL-C),triglyceride(TG)/high density lipoprotein cholesterol(HDL-C),serum phosphate,parathyroid hormone(PTH),interleukin-6(IL-6),matrix metalloproteinase-9(MMP-9)and p-cresol sulfate were higher than those in non-CVD group(all P＜0.05).Logistic multivariate regression analysis showed that the decreases of hemoglobin and Klotho protein and the increases of TG/HDL-C,IL-6 and p-cresol sulfate were independent risk factors of CVD in patients with CRF undergoing maintenance hemodialysis(all P＜0.05).Conclu-sion:The decreases of hemoglobin and Klotho protein and the increases of TG/HDL-C,IL-6 and p-cresol sulfate can increase the risk of CVD in patients with CRF undergoing maintenance hemodialysis,and it is necessary to strengthen the evaluation and management of these risk factors during hemodialysis treatment.关键词
慢性肾衰竭/心血管疾病/危险因素/Klotho蛋白/硫酸对甲酚Key words
Chronic renal failure/Cardiovascular diseases/Risk factors/Klotho protein/P-cresol sulfate分类
临床医学引用本文复制引用
姚律,黄小抗,朱琼..慢性肾衰竭患者并发心血管疾病相关危险因素分析[J].陕西医学杂志,2024,53(1):55-58,63,5.基金项目
安徽省高校自然科学研究项目(2022AH04032) （2022AH04032）
