赵嘉欣 1黄文海 1张俊鸿 1迟嘉墨 1王泽慧 1夏猛1
作者信息
摘要
Abstract
Objective To explore the intervention effect of lychee seed aromatherapy on hippocampus and serum 5-hydroxytryptamine(5-HT)and dopamine(DA)in chronic unpredictable mild stress(CUMS)de-pression model rats.Methods The isolatedfeed model rats withchronic unpredictable mild stress were used as the research object,the body weight gain and sugar and water consumption of rats in each group were recorded and calculated on the 7th,14th,21st and 28th days of the experiment.The contents of excitatory neurotrans-mitters 5-HT and DA in hippocampus and serum of rats in each group were detected after treatment on the 35th day of the experiment.Results(1)Weight gain:From 14th to 21st day,compared with the blank group,the weight gain of rats in the model group,the prozac group and the prozac supplemented aromatherapy group was decreased(P＜0.01)at the 14th to 21st day;From the 28th to the 35th day,compared with the blank group,the weight gain of rats in the model group decreased(P＞0.05),compared with the model group,the weight gain of rats in the prozac group and the prozac supplemented aromatherapy group increased(P＞0.05),compared with the prozac supplemented aromatherapy group,the weight gain of rats in the prozac group increased(P＞0.05).The number of body weight gain of rats in the prozac supplemented aromatherapy group was increased(P＜0.01).(2)Changes in sugar water consumption:on the 14th and 21st day,compared with the blank group,rats in the model group,the prozac group and the prozac supplemented aromatherapy group all decreased(P＜0.01);On the 35th day,compared with the blank group,the number of rats in the model group decreased(P＜0.01),the number of rats in the prozac group decreased(P＜0.05),the number of rats in the prozac group supplemented with aromatherapy decreased(P＞0.05),and the number of rats in the prozac group increased(P＜0.05),while the number of rats in the model group increased(P＜0.05).The number of rats in the prozacsupplemented aromatherapy group increased(P＜0.01);Compared with the prozac group,the number of rats in the prozac supplemented aromatherapy group was increased(P＜0.05).(3)Compared with the blank group,5-HT and DA concentrations in the model group and the prozac group were significantly decreased(P＜0.01),and 5-HT and DA concentrations in the prozac supplemented aroma-therapy group were significantly decreased(P＞0.05).Compared with the model group,the concentrations of 5-HT and DA in the blank group,the prozac group and the prozac supplemented aromatherapy group were significantly increased(P＜0.01).Compared with the prozac group,the concentrations of 5-HT and DA in the prozac supplemented aromatherapy group were significantly increased(P＜0.05).Conclusion Lychee seed ar-omatherapy can increase the content of monoamine neurotransmitters in the depressed model rats.The anti-depression mechanism of lychee seed aromatherapy may be related to the increase of monoamine neurotrans-mitters in the brain.关键词
抑郁/大鼠/荔枝核/香薰疗法/5-羟色胺/多巴胺Key words
Depression/Rat/Lychee seed/Aromatherapy/5-hydroxytryptamine/Dopamine分类
医药卫生
