现代医药卫生2023，Vol.39Issue(24)：4167-4171,4176,6.DOI:10.3969/j.issn.1009-5519.2023.24.007
钠-葡萄糖协同转运蛋白2抑制剂对乳腺癌化疗患者的心血管保护作用研究
Study on the cardiovascular protective effect of sodium-glucose cotransporter 2 inhibitor in chemotherapy patients with breast cancer
摘要
Abstract
Objective To explore whether sodium-glucose cotransporter 2 inhibitor(SGLT-2i)can re-duce the cardiotoxicity of chemotherapy in breast cancer patients with type 2 diabetes mellitus.Methods A total of 62 patients with type 2 diabetes who were hospitalized for chemotherapy in the Department of Breast Surgery,the First Affiliated Hospital of Chongqing Medical University from January 2019 to June 2022 due to breast cancer were collected.Univariate covariance analysis(continuous variables)and logistic regression(cate-gorical variables)were used to determine the effect of SGLT-2ioncardiotoxicity in breast cancer patients with type 2 diabetes after chemotherapy.Results SLGT-2itreatment shortened the PR interval of breast cancer pa-tients after chemotherapy[MD=-10.58,95％CI(-21.03,-0.14),P=0.047].There was no significant effect on left ventricular ejection fraction[MD=1.38,95％CI(-1.90,4.66),P=0.405],left atrial diameter[MD=-0.84,95％CI(-3.13,1.45),P=0.470],left ventricular end-diastolic diameter[MD=0.11,95％CI(-2.38,2.61),P=0.927],interventricular septum end-diastolic thickness[MD=-0.32,95％CI(-0.91,0.26),P=0.271],left ventricular posterior wall end-diastolic thickness[MD=-0.06,95％CI(-1.53,1.41),P=0.932]and QTc interval[MD=-6.19,95％CI(-19.38,7.00),P=0.357].SGLT-2i had no significant effect on the efficacy of anthracyclines or trastuzumab[OR=0.82,95％CI(0.05,12.82),P=0.885].In terms of hypoglycemic effect,SGLT-2i was comparable to other hypoglycemic drugs[MD=-0.80,95％CI(-1.62,0.03),P=0.057].In terms of adverse reactions,SGLT-2i did not cause additional renal function damage[MD=2.37,95％CI(-5.33,10.06),P=0.547].Conclusion SGLT-2i does not affect the efficacy of anthracyclines or trastuzumab in patients with breast cancer,and can reduce the prolongation of PR interval after chemotherapy.However,theeffect of SGLT-2i on cardiac structure and function after chemo-therapy needs to be further explored.关键词
SGLT-2抑制剂/蒽环类药物/曲妥珠单抗/肿瘤心脏毒性/乳腺癌Key words
Sodium-glucose cotransporter 2 inhibitors/Anthracycline drugs/Trastuzumab/Tumor cardiotoxicity/Breast cancer分类
医药卫生引用本文复制引用
陈杰,刘运波,毛敏,常静..钠-葡萄糖协同转运蛋白2抑制剂对乳腺癌化疗患者的心血管保护作用研究[J].现代医药卫生,2023,39(24):4167-4171,4176,6.基金项目
重庆市自然科学基金项目(cstc2020jcyj-msxmX0853). （cstc2020jcyj-msxmX0853）
