湖北科技学院学报（医学版）2023，Vol.37Issue(6)：481-485,5.DOI:10.16751/j.cnki.2095-4646.2023.06.0481
Box-Behnken响应面法结合多指标综合评分法对青钱柳提取工艺的优化研究
Optimization of Extraction Process of Cyclocarya Paliurus by Box-Behnken Response Surface Methodology Combined with Multiple Index Comprehensive Scoring
摘要
Abstract
Objective Box-Behnken response surface methodology was used to optimize the extraction process of Cyclocarya paliurus using the extraction of total flavonoids,total triterpenes and total polysaccharides as indicators.Methods Box-Behnken response surface methodology was used to optimize the extraction process on the basis of single factor experiment,with ethanol volume fraction,material-liquid ratio,extraction time and temperature as influencing factors,extraction rates of total flavonoids,total triterpenes,total polysaccharides and comprehensive scores obtained from total amount of three components as evaluation indexes.Results The best extraction process of C.paliurus was obtained by single factor test combined with Box-Behnken response surface methodology:ethanol volume fraction was 45%,material-iquid ratio was 1∶30,extraction time was 100 min,temperature was 60℃,extraction times was 3 times.The validation experiment proves that the process parameter was accurate and reliable.Conclusion Box-Behnken response surface method combined with multi-index com-prehensive scoring method can be used to optimize the extraction process of C.paliurus.The optimal extraction process is stable and feasible,and can lay a foundation for rational utilization and resource development of C.paliurus.关键词
青钱柳/Box-Behnken响应面法/层次分析法Key words
Cyclocarya paliurus/Box-Behnken response surface methodology/Analytic hierarchy process分类
药学引用本文复制引用
张丹丹,李利华,杨玉莹,叶晓川..Box-Behnken响应面法结合多指标综合评分法对青钱柳提取工艺的优化研究[J].湖北科技学院学报（医学版）,2023,37(6):481-485,5.基金项目
湖北省技术创新专项(重点项目)(2019AFB865) （重点项目）
糖尿病心脑血管病变湖北省重点实验室开放基金项目(2022TNB05) （2022TNB05）
