湖北科技学院学报（医学版）2023，Vol.37Issue(6)：486-490,505,6.DOI:10.16751/j.cnki.2095-4646.2023.06.0486
环磷酰胺聚乳酸微球的制备及其缓释过程的研究
Preparation of Cyclophosphamide Polylactic Acid Microspheres and Study on Their Sustained Release Process
摘要
Abstract
Objective To prepare cyclophosphamide polylactic acid microspheres and test the sustained release effect of microspheres in vitro.Methods Drug-loaded microspheres were prepared by O/W emulsion solvent evaporation method,and the preparation process was optimized by single factor experiment.The morphol-ogy of microspheres was observed by biomicroscope,and the particle size was analyzed by laser particle size an-alyzer.The drug loading,encapsulation efficiency and drug release in vitro of cyclophosphamide polylactic acid microspheres were studied by ultraviolet-visible spectrometry.Results The microspheres were spherical with a diameter of(12.67±3.67)μm.The drug loading and encapsulation rates were 15.38%and 62.5%,respec-tively,with a cumulative release time of 108 h and a cumulative release rate of 84.07%.Conclusion Cyclo-phosphamide polylactic acid microspheres were successfully prepared in this study,which provided a reference for the preparation of biodegradable drug-loaded microspheres.关键词
环磷酰胺/聚乳酸/微球/体外模拟Key words
Cyclophosphamide/Polylactic acid/Microspheres/Simulation in vitro分类
医药卫生引用本文复制引用
吴慧敏,钱文斌..环磷酰胺聚乳酸微球的制备及其缓释过程的研究[J].湖北科技学院学报（医学版）,2023,37(6):486-490,505,6.基金项目
校国家级科研项目培育计划项目(2021-23GP03) （2021-23GP03）
