摘要
Abstract
Objective To observe and analyze the application effect of sufentanil and dexmedetomidine in the process of surgical anesthesia and postoperative analgesia.Methods A total of 154 patients who under-went general anesthesia in the hospital from October 2021 to October 2022 were observed and divided into the routine group and the combined group by digital random table method,with 77 patients in each group.Among them,fentanyl was used in the routine group during clinical anesthesia,sufentanil was used in combination with postoperative analgesia,sufentanil was used in the combination group during clinical anesthesia,and dexmedetomidine was used in combination with postoperative analgesia.Results The postoperative recovery time of consciousness,spontaneous breathing and extubation time in the combined group were shorter than those in the routine group,with statistical significance(P＜0.05).The pain Visual Analogu Scale(VAS)at 2,6,12 and 24 hours after operation.and the sleep quality score at 24,48 and 72 hours after operation in the com-bined group were lower than those in the routine group,with statistical significance(P＜0.05).The expres-sion levels of cortisol and interleukin-6(IL-6)in the combined group were lower than those in the routine group 48 hours after operation,and the difference was statistically significant(P＜0.05).The adverse reac-tions such as retching,bradycardia and drowsiness in the combined group were less than those in the routine group,and the differences were statistically significant(P＜0.05).Conclusion The application of sufentanil in clinical anesthesia and dexmedetomidine in postoperative analgesia can significantly improve anesthesia effect,inhibit pain stress,improve patients'sleep quality and reduce adverse reactions,which is worthy of extensive reference.关键词
临床麻醉/术后镇痛/右美托咪定/舒芬太尼/疼痛/睡眠质量Key words
Clinical anesthesia/Postoperative analgesia/Dexmedetomidine/Sufentanil/Pain/Sleep quality分类
医药卫生
