湖北科技学院学报（医学版）2023，Vol.37Issue(6)：495-498,4.DOI:10.16751/j.cnki.2095-4646.2023.06.0495
山奈酚微孔渗透泵片的制备工艺研究
Preparation and Evaluation of Micro-Porosity Osmotic Pump Tablets Containing Kaempferol
赵堂开 1葛婷婷 1王琢文 1张雨晨 2要辉 2闵清 2白育庭3
作者信息
- 1. 湖北科技学院医学部药学院,湖北 咸宁 437100||湖北科技学院医学部临床医学院||湖北科技学院鄂南特色中药湖北省工程研究中心
- 2. 湖北科技学院医学部药学院,湖北 咸宁 437100||湖北科技学院鄂南特色中药湖北省工程研究中心
- 3. 湖北科技学院医学部临床医学院
- 折叠
摘要
Abstract
Objective To design and prepare kaempferol microporous osmotic pump tablets.Methods The kaempferol microporous osmotic pump tablet were prepared using lactose and sodium chloride as penetra-tion enhancers,diethyl phthalate and cellulose acetate as membrane forming materials,and polyethylene glycol PEG 400 as pore forming agent.Results When the dosage of sodium chloride in the core was 15.0%,lactose was 30.0%,coating weight gain was 4.0%of the core,and the dosage of pore forming agent PEG 400 was 40.0%,the drug release rate was optimal,and the cumulative release rate after 12 hours reached over 85%.Conclusion The preparation process of the kaempferol microporous osmotic pump tablets was simple and had good reproducibility.The prepared kaempferol microporous osmotic pump tablets could achieve the expected controlled release effect.关键词
山奈酚/微孔渗透泵片/药物释放/最优处方Key words
Kaempferol/Microporous osmotic pump tablets/Drug release/Optimal prescription分类
医药卫生引用本文复制引用
赵堂开,葛婷婷,王琢文,张雨晨,要辉,闵清,白育庭..山奈酚微孔渗透泵片的制备工艺研究[J].湖北科技学院学报（医学版）,2023,37(6):495-498,4.
